Reduction of blood glucose by plant extracts and their use in the treatment of diabetes mellitus; discrepancies in effectiveness between animal and human studies

BL Furman, M Candasamy, SK Bhattamisra… - Journal of …, 2020 - Elsevier
Ethnopharmacological relevance The global problem of diabetes, together with the limited
access of large numbers of patients to conventional antidiabetic medicines, continues to …

Glycosidase inhibitors: a patent review (2008–2013)

NF Brás, NM Cerqueira, MJ Ramos… - Expert Opinion on …, 2014 - Taylor & Francis
Introduction: In the recent decades, the interest on glycosidases has dramatically increased,
mainly because these enzymes play a key role in many biological processes. The …

Structural requirements of flavonoids for inhibition of protein glycation and radical scavenging activities

H Matsuda, T Wang, H Managi, M Yoshikawa - Bioorganic & medicinal …, 2003 - Elsevier
To clarify the structural requirements of flavonoids for formation of advanced glycation end-
products (AGEs), various flavonoids were examined. The results suggested the following …

Characterization of inhibitors of postprandial hyperglycemia from the leaves of Nerium indicum

A Ishikawa, H Yamashita, M Hiemori… - Journal of nutritional …, 2007 - jstage.jst.go.jp
Nerium indicum is an India-Pakistan-originated shrub belonging to the oleander family. The
ingestion of leaves of N. indicum before a meal is known to effect the lowering of …

Inhibitory effect on α-glucosidase by the fruits of Terminalia chebula Retz.

H Gao, YN Huang, PY Xu, J Kawabata - Food Chemistry, 2007 - Elsevier
Mammalian α-glucosidase inhibitory activity by Terminalia chebula Retz. fruits was
investigated. The aqueous methanolic extract was found to have potent rat intestinal maltase …

Potent anti-obese principle from Rosa canina: structural requirements and mode of action of trans-tiliroside

K Ninomiya, H Matsuda, M Kubo, T Morikawa… - Bioorganic & medicinal …, 2007 - Elsevier
The 80% aqueous acetone extracts from the fruit (50mg/kg/d) and seeds (12.5 and
25mg/kg/d) of Rosa canina L., but not from the pericarps, were found to show substantial …

Medicinal flowers. XII. 1) New spirostane-type steroid saponins with antidiabetogenic activity from Borassus flabellifer

M Yoshikawa, F Xu, T Morikawa… - Chemical and …, 2007 - jstage.jst.go.jp
The methanolic extract from the male flowers of Borassus flabellifer was found to inhibit the
increase of serum glucose levels in sucrose-loaded rats at a dose of 250mg/kg, po. From the …

Antidiabetogenic constituents from several natural medicines

H Matsuda, T Morikawa, M Yoshikawa - Pure and Applied Chemistry, 2002 - degruyter.com
In the course of our studies on antidiabetogenic and antidiabetic principles of natural
medicines and medicinal foodstuffs, we have isolated salacinol and kotalanol with unique …

Design and synthesis of sulfonium derivatives: a novel class of α-glucosidase inhibitors with potent in vivo antihyperglycemic activities

L Lu, J Chen, W Tao, Z Wang, D Liu… - Journal of Medicinal …, 2023 - ACS Publications
We report the first attempt of double-spot structural modification on a side-chain moiety of
sulfonium-type α-glucosidase inhibitors isolated from genus Salacia. A series of sulfonium …

An Expeditious Route to trans‐Configured Tetrahydrothiophenes Enabled by Fe(OTf)3‐Catalyzed [3+2] Cycloaddition of Donor–Acceptor Cyclopropanes with …

Y Matsumoto, D Nakatake, R Yazaki… - … –A European Journal, 2018 - Wiley Online Library
A synthetic route to trans‐configured tetrahydrothiophenes (THTs) through Fe (OTf) 3‐
promoted [3+ 2] cycloaddition of donor–acceptor cyclopropanes with thionoesters was …