Brown adipose tissue—a translational perspective

AC Carpentier, DP Blondin, F Haman… - Endocrine …, 2023 - academic.oup.com
Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Substrate utilization by brown adipose tissue: what's hot and what's not?

BT McNeill, NM Morton, RH Stimson - Frontiers in endocrinology, 2020 - frontiersin.org
Our understanding of brown adipose tissue (BAT) function in humans has increased rapidly
over the past 10 years. This is predominantly due to the development of powerful non …

A mast cell–thermoregulatory neuron circuit axis regulates hypothermia in anaphylaxis

C Bao, O Chen, H Sheng, J Zhang, Y Luo… - Science …, 2023 - science.org
IgE-mediated anaphylaxis is an acute life-threatening systemic reaction to allergens,
including certain foods and venoms. Anaphylaxis is triggered when blood-borne allergens …

Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota

BA Ahmed, FJ Ong, NG Barra, DP Blondin, E Gunn… - Cell Reports …, 2021 - cell.com
In rodents, lower brown adipose tissue (BAT) activity is associated with greater liver
steatosis and changes in the gut microbiome. However, little is known about these …

Basal and cold-induced fatty acid uptake of human brown adipose tissue is impaired in obesity

TJ Saari, J Raiko, M U-Din, T Niemi, M Taittonen… - Scientific Reports, 2020 - nature.com
Fatty acids (FA) are important substrates for brown adipose tissue (BAT) metabolism,
however, it remains unclear whether there exists a difference in FA metabolism of BAT …

High-fructose feeding suppresses cold-stimulated brown adipose tissue glucose uptake independently of changes in thermogenesis and the gut microbiome

G Richard, DP Blondin, SA Syed, L Rossi… - Cell Reports …, 2022 - cell.com
Diets rich in added sugars are associated with metabolic diseases, and studies have shown
a link between these pathologies and changes in the microbiome. Given the reported …

Magnetic resonance imaging techniques for brown adipose tissue detection

M Wu, D Junker, RT Branca… - Frontiers in …, 2020 - frontiersin.org
Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) methods
can non-invasively assess brown adipose tissue (BAT) structure and function. Recently, MRI …

Tracers and imaging of fatty acid and energy metabolism of human adipose tissues

AC Carpentier - Physiology, 2024 - journals.physiology.org
White adipose tissue and brown adipose tissue (WAT and BAT) regulate fatty acid
metabolism and control lipid fluxes to other organs. Dysfunction of these key metabolic …

Molecular imaging of brown adipose tissue mass

J Yang, H Zhang, K Parhat, H Xu, M Li, X Wang… - International Journal of …, 2021 - mdpi.com
Brown adipose tissue (BAT), a uniquely thermogenic tissue that plays an important role in
metabolism and energy expenditure, has recently become a revived target in the fight …

Weather permitting: Increased seasonal efficiency of nonshivering thermogenesis through brown adipose tissue activation in the winter

A Niclou, C Ocobock - American Journal of Human Biology, 2022 - Wiley Online Library
Objectives We investigated seasonal changes in brown adipose tissue (BAT) activation and
metabolism in a temperate‐climate Albany, NY population. Methods Data were collected …