Traditionally, clinical pharmacology has focused its activities on drug-organism interaction,
from an individual or collective perspective. Drug efficacy assessment by performing …

Abstract Background Real-World Data (RWD) studies provide important insights in disease
epidemiology, in real clinical populations, with long follow-up periods. The aim of the …

Background Estimate the incidence of herpes zoster (HZ), its complications and healthcare
utilization rates in adults (≥ 18-years-old) with a wide range of immunocompromised (IC) …

Background: The opioid epidemic has been extensively documented in the United States
and Canada, but fewer data are available for Europe. Aim: To describe the trends in opioid …

Background: In March 2018, the European pregnancy prevention programme for oral
retinoids was updated as part of risk minimisation measures (RMM), emphasising their …

Objective To identify individual and initial prescription-related factors associated with an
increased risk for opioid-related misuse, poisoning and dependence (MPD) in patients with …

An association exists between severe respiratory syncytial virus (RSV)–bronchiolitis and a
subsequent increased risk of recurrent wheezing (RW) and asthma. However, a causal …

Comparative frailty prevalence data across European countries is sparse due to
heterogeneous measurement methods. The Survey of Health, Ageing and Retirement …

Background Multi-state models are complex stochastic models which focus on pathways
defined by the temporal and sequential occurrence of numerous events of interest. In …

Purpose Long-term extension of a previous randomized controlled clinical trial comparing
open (OVHR) vs. laparoscopic (LVHR) ventral hernia repair, assessing recurrence …