The natural mammalian polyamines putrescine, spermidine and spermine are essential for
both normal and neoplastic cell function and replication. Dysregulation of metabolism of …

Adaptive immune responses mediated by T cells and B cells are crucial for protective
immunity against pathogens and tumors. Differentiation and function of immune cells require …

Diabetic kidney disease (DKD) occurs in∼ 40% of patients with diabetes and causes kidney
failure, cardiovascular disease, and premature death. We analyzed the response of a …

Realizing the full utility of brain organoids to study human development requires
understanding whether organoids precisely replicate endogenous cellular and molecular …

Since their discovery almost two decades ago, interleukin-17-producing CD4+ T cells (TH17
cells) have been implicated in the pathogenesis of multiple autoimmune and inflammatory …

There is a need to develop effective therapies for pancreatic ductal adenocarcinoma (PDA),
a highly lethal malignancy with increasing incidence and poor prognosis. Although targeting …

While intestinal Th17 cells are critical for maintaining tissue homeostasis, recent studies
have implicated their roles in the development of extra-intestinal autoimmune diseases …

RORγt, the master transcription factor for cytokine interleukin (IL)-17, is expressed explicitly
in Th17 cells, γδT cells, and type 3 innate lymphoid cells in mice and humans. Since …

Aging involves the systemic deterioration of all known cell types in most eukaryotes. Several
recently discovered compounds that extend the healthspan and lifespan of model organisms …

Large-scale fecal shotgun metagenomic sequencing revealed the high abundance of
Parvimonas micra in colorectal cancer (CRC) patients. We investigated the role and clinical …