Cellular functions of eukaryotic RNA helicases and their links to human diseases

KE Bohnsack, S Yi, S Venus, E Jankowsky… - … Reviews Molecular Cell …, 2023 - nature.com
RNA helicases are highly conserved proteins that use nucleoside triphosphates to bind or
remodel RNA, RNA–protein complexes or both. RNA helicases are classified into the DEAD …

EGFR signaling pathway as therapeutic target in human cancers

E Levantini, G Maroni, M Del Re, DG Tenen - Seminars in cancer biology, 2022 - Elsevier
Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …

Epidermal growth factor receptor cell proliferation signaling pathways

P Wee, Z Wang - Cancers, 2017 - mdpi.com
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …

The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer

JL Hsu, MC Hung - Cancer and Metastasis Reviews, 2016 - Springer
Breast cancer affects approximately 1 in 8 women, and it is estimated that over 246,660
women in the USA will be diagnosed with breast cancer in 2016. Breast cancer mortality has …

Targeting the EGFR signaling pathway in cancer therapy

P Seshacharyulu, MP Ponnusamy… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: Cancer is a devastating disease; however, several therapeutic advances have
recently been made, wherein EGFR and its family members have emerged as useful …

EGFR signaling enhances aerobic glycolysis in triple-negative breast cancer cells to promote tumor growth and immune escape

SO Lim, CW Li, W Xia, HH Lee, SS Chang, J Shen… - Cancer research, 2016 - AACR
Oncogenic signaling reprograms cancer cell metabolism to augment the production of
glycolytic metabolites in favor of tumor growth. The ability of cancer cells to evade …

Nuclear EGFR as a molecular target in cancer

TM Brand, M Iida, N Luthar, MM Starr… - Radiotherapy and …, 2013 - Elsevier
The epidermal growth factor receptor (EGFR) has been one of the most targeted receptors in
the field of oncology. While anti-EGFR inhibitors have demonstrated clinical success in …

[HTML][HTML] The nuclear epidermal growth factor receptor signaling network and its role in cancer

TM Brand, M Iida, C Li, DL Wheeler - Discovery medicine, 2011 - ncbi.nlm.nih.gov
The epidermal growth factor receptor (EGFR) is a member of the EGFR family of receptor
tyrosine kinases (RTKs). EGFR activation via ligand binding results in signaling through …

Landscape of EGFR signaling network in human cancers: biology and therapeutic response in relation to receptor subcellular locations

W Han, HW Lo - Cancer letters, 2012 - Elsevier
The epidermal growth factor receptor (EGFR) pathway is one of the most dysregulated
molecular pathways in human cancers. Despite its well-established importance in tumor …

Tyrosine kinase receptors in oncology

J Esteban-Villarrubia, JJ Soto-Castillo, J Pozas… - International journal of …, 2020 - mdpi.com
Tyrosine kinase receptors (TKR) comprise more than 60 molecules that play an essential
role in the molecular pathways, leading to cell survival and differentiation. Consequently …