Brain waste removal system and sleep: Photobiomodulation as an innovative strategy for night therapy of brain diseases

O Semyachkina-Glushkovskaya, I Fedosov… - International journal of …, 2023 - mdpi.com
Emerging evidence suggests that an important function of the sleeping brain is the removal
of wastes and toxins from the central nervous system (CNS) due to the activation of the brain …

The crosstalk between the blood–brain barrier dysfunction and neuroinflammation after general anaesthesia

X Yang, X Chen - Current issues in molecular biology, 2022 - mdpi.com
As we know, with continuous medical progress, the treatment of many diseases can be
conducted via surgery, which often relies on general anaesthesia for its satisfactory …

[HTML][HTML] Factors predisposing to humoral autoimmunity against brain-antigens in health and disease: Analysis of 49 autoantibodies in over 7000 subjects

VD Gastaldi, JBH Wilke, CA Weidinger, C Walter… - Brain, Behavior, and …, 2023 - Elsevier
Background Circulating autoantibodies (AB) against brain-antigens, often deemed
pathological, receive increasing attention. We assessed predispositions and …

Reduced malignant glioblastoma recurrence post-resection through the anti-CD47 antibody and Temozolomide co-embedded in-situ hydrogel system

L Ye, W Lv, W He, S Li, Z Min, L Gong, Q Zhang… - Journal of Controlled …, 2023 - Elsevier
Infiltrative glioma growth makes surgical excision incomplete, and the residual tumor cells
proliferate rapidly. Residual glioma cells evade phagocytosis by macrophages through …

The Effects of Propofol on a Human in vitro Blood-Brain Barrier Model

JM Hughes, OR Neese, DD Bieber… - Frontiers in Cellular …, 2022 - frontiersin.org
Background Recently, the safety of repeated and lengthy anesthesia administration has
been called into question, a subset of these animal studies demonstrated that anesthetics …

Detrimental Effects of ApoE ε4 on Blood–Brain Barrier Integrity and Their Potential Implications on the Pathogenesis of Alzheimer's Disease

K Kirchner, L Garvert, L Kühn, S Bonk, HJ Grabe… - Cells, 2023 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease representing the most
common type of dementia in older adults. The major risk factors include increased age …

Effects of volatile anesthetics versus ketamine on blood-brain barrier permeability via lipid-mediated alterations of endothelial cell membranes

B Noorani, EA Chowdhury, F Alqahtani, Y Ahn… - … of Pharmacology and …, 2023 - ASPET
The purpose of this study was to investigate the effects of the volatile anesthetic agents
isoflurane and sevoflurane, at clinically relevant concentrations, on the fluidity of lipid …

Anesthesia effects in rat electrocorticograms characterized using detrended fluctuation analysis and its extension

GA Guyo, AN Pavlov… - The European Physical …, 2024 - Springer
Using rat electrocorticograms (ECoG), we discuss how detrended fluctuation analysis (DFA)
and its recently proposed extension characterize anesthesia effects in the electrical activity …

The Acute Impact of Propofol on Blood–Brain Barrier Integrity in Mice

E Nozohouri, Y Ahn, S Zoubi, D Patel, SR Archie… - Pharmaceutical …, 2024 - Springer
Purpose We investigated whether short term infusion of propofol, a highly lipophilic agonist
at GABAA receptors, which is in widespread clinical use as anesthetic and sedative, affects …

Mesoscopic mapping of hemodynamic responses and neuronal activity during pharmacologically induced interictal spikes in awake and anesthetized mice

J Li, F Yang, F Zhan, J Estin, A Iyer… - Journal of Cerebral …, 2024 - journals.sagepub.com
Imaging hemodynamic responses to interictal spikes holds promise for presurgical epilepsy
evaluations. Understanding the hemodynamic response function is crucial for accurate …