Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other; the
comorbidity of these brain disorders in aging individuals represents a significant challenge …

In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased
oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression …

Abstract NMDA (N-methyl-d-aspartate) receptors (NMDARs) play a central role in excitotoxic
neuronal death caused by ischemic stroke, but NMDAR channel blockers have failed to be …

Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by
cognitive dysfunction and synaptic failure. The current therapeutic approaches are mainly …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

N-methyl-d-aspartate receptors (NMDARs) are located in neuronal cell membranes at
synaptic and extrasynaptic locations, where they are believed to mediate distinct …

Recanalization therapy is increasingly used in the treatment of acute ischemic stroke.
However, in about one third of these patients, recanalization is followed by …

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate
chemical communication between neurons at synapses. A variant iGluR subfamily, the …