Prevalence and disease burden of chronic kidney disease

JC Lv, LX Zhang - Renal fibrosis: mechanisms and therapies, 2019 - Springer
Chronic kidney disease (CKD) has been recognized as a leading public health problem
worldwide. The global estimated prevalence of CKD is 13.4%(11.7–15.1%), and patients …

[HTML][HTML] Extracellular vesicles in kidney disease

C Grange, B Bussolati - Nature Reviews Nephrology, 2022 - nature.com
Extracellular vesicles are released by the majority of cell types and circulate in body fluids.
They function as a long-distance cell-to-cell communication mechanism that modulates the …

[HTML][HTML] Exosomes and microvesicles in normal physiology, pathophysiology, and renal diseases

A Ståhl, K Johansson, M Mossberg, R Kahn… - Pediatric …, 2019 - Springer
Extracellular vesicles are cell-derived membrane particles ranging from 30 to 5,000 nm in
size, including exosomes, microvesicles, and apoptotic bodies. They are released under …

Induced pluripotent stem cell (iPSC)–derived extracellular vesicles are safer and more effective for cardiac repair than iPSCs

M Adamiak, G Cheng, S Bobis-Wozowicz… - Circulation …, 2018 - Am Heart Assoc
Rationale: Extracellular vesicles (EVs) are tiny membrane-enclosed droplets released by
cells through membrane budding or exocytosis. The myocardial reparative abilities of EVs …

AKI: an increasingly recognized risk factor for CKD development and progression

JT Kurzhagen, S Dellepiane, V Cantaluppi… - Journal of …, 2020 - Springer
Acute kidney injury (AKI) is an increasing health burden with high morbidity and mortality
rates worldwide. AKI is a risk factor for chronic kidney disease (CKD) development and …

Extracellular vesicles: evolving factors in stem cell biology

M Nawaz, F Fatima, KC Vallabhaneni… - Stem cells …, 2016 - Wiley Online Library
Stem cells are proposed to continuously secrete trophic factors that potentially serve as
mediators of autocrine and paracrine activities, associated with reprogramming of the tumor …

Extracellular vesicles in diagnosis and therapy of kidney diseases

W Zhang, X Zhou, H Zhang, Q Yao… - American Journal of …, 2016 - journals.physiology.org
Extracellular vesicles (EV) are endogenously produced, membrane-bound vesicles that
contain various molecules. Depending on their size and origins, EVs are classified into …

[HTML][HTML] Detrimental cross-talk between sepsis and acute kidney injury: new pathogenic mechanisms, early biomarkers and targeted therapies

S Dellepiane, M Marengo, V Cantaluppi - Critical Care, 2016 - Springer
This article is one of ten reviews selected from the Annual Update in Intensive Care and
Emergency medicine 2016. Other selected articles can be found online at http://www …

[HTML][HTML] Exosomes as drug delivery systems: endogenous nanovehicles for treatment of systemic lupus erythematosus

A Ortega, O Martinez-Arroyo, MJ Forner, R Cortes - Pharmaceutics, 2021 - mdpi.com
Exosomes, nanometer-sized lipid-bilayer-enclosed extracellular vesicles (EVs), have
attracted increasing attention due to their inherent ability to shuttle proteins, lipids and genes …

[HTML][HTML] Extracellular vesicles as mediators of cellular crosstalk between immune system and kidney graft

M Quaglia, S Dellepiane, G Guglielmetti… - Frontiers in …, 2020 - frontiersin.org
Extracellular vesicles (EVs) are known immune-modulators exerting a critical role in kidney
transplantation (KT). EV bioactive cargo includes graft antigens, costimulatory/inhibitory …