[HTML][HTML] Stabilizing the neural barrier–A novel approach in pain therapy

AK Reinhold, B Hartmannsberger, M Burek… - Pharmacology & …, 2023 - Elsevier
Chronic and neuropathic pain are a widespread burden. Incomplete understanding of
underlying pathomechanisms is one crucial factor for insufficient treatment. Recently …

Regenerative effects of heme oxygenase metabolites on neuroinflammatory diseases

H Lee, YK Choi - International journal of molecular sciences, 2018 - mdpi.com
Heme oxygenase (HO) catabolizes heme to produce HO metabolites, such as carbon
monoxide (CO) and bilirubin (BR), which have gained recognition as biological signal …

Puerarin reverses cadmium-induced lysosomal dysfunction in primary rat proximal tubular cells via inhibiting Nrf2 pathway

LY Wang, RF Fan, DB Yang, D Zhang… - Biochemical pharmacology, 2019 - Elsevier
Previous studies have shown that oxidative stress-induced inhibition of autophagy plays a
pivotal role in cadmium (Cd)-mediated cytotoxicity in primary rat proximal tubular (rPT) cells …

Effect of autophagy regulated by Sirt1/FoxO1 pathway on the release of factors promoting thrombosis from vascular endothelial cells

Q Wu, Y Hu, M Jiang, F Wang, G Gong - International journal of molecular …, 2019 - mdpi.com
Factors promoting thrombosis such as von Willebrand factor (vWF) and P-selectin are
essential for the development of atherosclerosis (AS) and arterial thrombosis. The …

Homer1 protects against retinal ganglion cell pyroptosis by inhibiting endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation after middle …

W Lv, X Wu, Y Dou, Y Yan, L Chen, Z Fei… - International Journal of …, 2023 - mdpi.com
Retinal ischemia, after cerebral ischemia, is an easily overlooked pathophysiological
problem in which inflammation is considered to play an important role. Pyroptosis is a kind of …

Haematococcus pluvialis-Derived Astaxanthin Is a Potential Neuroprotective Agent against Optic Nerve Ischemia

WN Lin, K Kapupara, YT Wen, YH Chen, IH Pan… - Marine drugs, 2020 - mdpi.com
Astaxanthin, a xanthophyll belonging to the family of carotenoids, is a potent antioxidant.
However, much less is known about its protective effects on the oxidative stress of ischemic …

mTORC2 activation protects retinal ganglion cells via Akt signaling after autophagy induction in traumatic optic nerve injury

YT Wen, JR Zhang, K Kapupara, RK Tsai - Experimental & molecular …, 2019 - nature.com
Traumatic optic neuropathy is an injury to the optic nerve that leads to vision loss. Autophagy
is vital for cell survival and cell death in central nervous system injury, but the role of …

Vitamin B3 provides neuroprotection via antioxidative stress in a rat model of anterior ischemic optic neuropathy

TW Chen, PY Wu, YT Wen, TD Desai, CT Huang… - Antioxidants, 2022 - mdpi.com
Supplementing with vitamin B3 has been reported to protect against retinal ganglion cell
(RGC) damage events and exhibit multiple neuroprotective properties in a mouse model of …

Platelet-derived circulating soluble P-selectin is sufficient to induce hematopoietic stem cell mobilization

TF Wang, YS Liou, SH Yang, GL Lin… - Stem Cell Research & …, 2023 - Springer
Background Granulocyte colony-stimulating factor (G-CSF)-mediated mobilization of
hematopoietic stem cells (HSCs) is a well-established method to prepare HSCs for …

Resveratrol protects photoreceptors by blocking caspase-and PARP-dependent cell death pathways

SY Liu, JY Song, B Fan, Y Wang, YR Pan, L Che… - Free Radical Biology …, 2018 - Elsevier
Retinal degeneration is a major cause of severe vision loss and irreversible blindness and is
characterized by progressive damage to retinal photoreceptor cells. Resveratrol (RSV) …