Targeting O-GlcNAcylation in cancer therapeutic resistance: The sugar Saga continues

L Chen, M Hu, L Chen, Y Peng, C Zhang, X Wang, X Li… - Cancer Letters, 2024 - Elsevier
Abstract O-linked-N-acetylglucosaminylation (O-GlcNAcylation), a dynamic post-
translational modification (PTM), holds profound implications in controlling various cellular …

Role of O-GlcNAcylation in Central Nervous System Development and Injuries: A Systematic Review

L Zhang, W Bai, Y Peng, Y Lin, M Tian - Molecular Neurobiology, 2024 - Springer
The development of central nervous system (CNS) can form perceptual, memory, and
cognitive functions, while injuries to CNS often lead to severe neurological dysfunction and …

Visible-Light-Mediated Dual Functionalization of Allenes: Regio-and Stereoselective Synthesis of Vinylsulfone Azides

H Guo, X Ruan, Z Xu, K Wang, X Li… - The Journal of Organic …, 2023 - ACS Publications
A gentle and effective method for the photocatalytic dual functionalization of allenes with
high regio-and stereoselectivity using a nonmetallic catalyst is described. Inexpensive and …

[HTML][HTML] O-GlcNAcase regulates pluripotency states of human embryonic stem cells

Q Liu, C Chen, Z Fan, H Song, Y Sha, L Yu, Y Wang… - Stem Cell Reports, 2024 - cell.com
Understanding the regulation of human embryonic stem cells (hESCs) pluripotency is critical
to advance the field of developmental biology and regenerative medicine. Despite the recent …

[HTML][HTML] The ubiquitin E3 ligase APC/CCdc20 mediates mitotic degradation of OGT

L Meng, R Dong, W Mi, K Qin, K Ouyang, J Sun… - Journal of Biological …, 2024 - Elsevier
SUMMARY O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is the sole
enzyme that catalyzes all O-GlcNAcylation reactions intracellularly. Previous investigations …

O-GlcNAcylation and Its Roles in Neurodegenerative Diseases

P Du, X Zhang, X Lian, C Hölscher… - Journal of Alzheimer's …, 2024 - content.iospress.com
As a non-classical post-translational modification, O-linked β-N-acetylglucosamine (O-
GlcNAc) modification (O-GlcNAcylation) is widely found in human organ systems …

Deciphering single-cell protein secretion and gene expressions by constructing cell-antibody conjugates

Y Li, W Li, J Chen, S Qiu, Y Liu, L Xu, T Tian, JP Li - Bioorganic Chemistry, 2024 - Elsevier
Secreted proteins play critical roles in regulating immune responses, exerting cytotoxic
effects on tumor cells, promoting inflammatory processes, and influencing cellular …

Energy Metabolism Pathways in Stem Cell Fate Regulation

M Wang, X Yang, H Cao - 2024 - preprints.org
Energy metabolism regulates the proliferation of stem cells by regulating energy production
and the production of substrates through biosynthetic pathways. It is an important target for …