Saltatory conduction of action potentials along myelinated axons depends on the nodes of
Ranvier—small unmyelinated axonal domains where voltage-gated sodium channels are …

The study of structural and functional plasticity in the central nervous system (CNS) to date
has focused primarily on that of neurons and synapses. However, more recent studies …

Microglia, the resident immune cells of the central nervous system, are key players in
healthy brain homeostasis and plasticity. In neurological diseases, such as Multiple …

Locomotion empowers animals to move. Locomotor-initiating signals from the brain are
funneled through descending neurons in the brainstem that act directly on spinal locomotor …

The spinal cord accounts for the main communication pathway between the brain and the
peripheral nervous system. Spinal cord injury is a devastating and largely irreversible …

Abstract Parvalbumin-expressing (PV+) basket cells are fast-spiking inhibitory interneurons
that exert critical control over local circuit activity and oscillations. PV+ axons are often …

Pain is a quite frequent complaint accompanying numerous pathologies. Among these
pathological cases, numerous neuropathies are retrieved with identified etiologies …

The D3 dopamine receptor, a member of the Gi-coupled D2 family of dopamine receptors, is
expressed throughout limbic circuits affected in neuropsychiatric disorders, including …

Neuronal signal transmission depends on the frequency, pattern, and timing of spike output,
each of which are shaped by spike afterhyperpolarizations (AHPs). There are classically …

Non-synaptic (intrinsic) plasticity of membrane excitability contributes to aspects of memory
formation, but it remains unclear whether it merely facilitates synaptic long-term potentiation …