Structure, function and polymorphism of human cytosolic sulfotransferases

Y Li, J Lindsay, LL Wang, SF Zhou - Current drug metabolism, 2008 - ingentaconnect.com
The sulfotransferase (SULTs) catalyzes the sulfonation of a multitude of xenobiotics,
hormones and neurotransmitters. This review has summarised the SULT family in detail, the …

[HTML][HTML] Sulfonation, an underexploited area: from skeletal development to infectious diseases and cancer

AWY Leung, I Backstrom, MB Bally - Oncotarget, 2016 - ncbi.nlm.nih.gov
Sulfonation is one of the most abundant cellular reactions modifying a wide range of
xenobiotics as well as endogenous molecules which regulate important biological …

Structural and dynamic characterizations highlight the deleterious role of SULT1A1 R213H polymorphism in substrate binding

R Dash, MC Ali, N Dash, MAK Azad… - International Journal of …, 2019 - mdpi.com
Sulfotransferase 1A1 (SULT1A1) is responsible for catalyzing various types of endogenous
and exogenous compounds. Accumulating data indicates that the polymorphism rs9282861 …

CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility

H Hirata, Y Hinoda, N Okayama, Y Suehiro… - Cancer, 2008 - Wiley Online Library
BACKGROUND. In estrogen biosynthetic pathways, many enzymes are important for
metabolism, detoxification, and bioavailability. Polymorphisms in these genes may have an …

GenX caused liver injury and potential hepatocellular carcinoma of mice via drinking water even at environmental concentration

G Wan, Z Zhang, J Chen, M Li, J Li - Environmental Pollution, 2024 - Elsevier
Hexafluoropropylene oxide dimer acid (GenX) is an alternative to perfluorooctanoic acid
(PFOA), whose environmental concentration is close to its maximum allowable value …

Detection and characterization of clostebol sulfate metabolites in Caucasian population

G Balcells, OJ Pozo, L Garrostas, A Esquivel… - … of Chromatography B, 2016 - Elsevier
Anabolic androgenic steroids (AAS) are synthetic testosterone derivatives which undergo
extensive metabolism in man. Differences in the excretion of phase II metabolites are …

Sulfotransferase genetic variation: from cancer risk to treatment response

J Daniels, S Kadlubar - Drug metabolism reviews, 2013 - Taylor & Francis
Cytosolic sulfotransferases (SULTs) are phase II detoxification enzymes that are involved in
the biotransformation of a wide variety of structurally diverse endo-and xenobiotics. Single …

Evaluation of sulfate metabolites as markers of intramuscular testosterone administration in Caucasian and Asian populations

A Esquivel, É Alechaga, N Monfort… - Drug testing and …, 2019 - Wiley Online Library
The introduction of alternative markers to the steroid profile can be an effective approach to
improving the screening capabilities for the detection of testosterone (T) misuse. In this work …

A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity

A Allali-Hassani, GA Wasney, I Chau… - Biochemical …, 2009 - portlandpress.com
On average, each human gene has approximately four SNPs (single nucleotide
polymorphisms) in the coding region, half of which are nsSNPs (non-synonymous SNPs) or …

Phase-II metabolism of androgens and its relevance for doping control analysis

T Kuuranne - Doping in Sports: Biochemical Principles, Effects and …, 2009 - Springer
Phase-II metabolism has a major contribution to androgen metabolism, converting the highly
non-polar compounds to a more easily excreted form prior to their excretion in urine. In the …