Amorphous solid dispersions: Rational selection of a manufacturing process
Amorphous products and particularly amorphous solid dispersions are currently one of the
most exciting areas in the pharmaceutical field. This approach presents huge potential and …
most exciting areas in the pharmaceutical field. This approach presents huge potential and …
A systematic and robust assessment of hot-melt extrusion-based amorphous solid dispersions: Theoretical prediction to practical implementation
Amorphous solid dispersions (ASDs) have gained attention as a formulation strategy in
recent years, with the potential to improve the apparent solubility and, hence, the oral …
recent years, with the potential to improve the apparent solubility and, hence, the oral …
Coupling 3D printing with hot-melt extrusion to produce controlled-release tablets
The main objective of this work was to explore the potential of coupling fused deposition
modeling in three-dimensional (3D) printing with hot-melt extrusion (HME) technology to …
modeling in three-dimensional (3D) printing with hot-melt extrusion (HME) technology to …
Hydroxypropyl methylcellulose-based controlled release dosage by melt extrusion and 3D printing: Structure and drug release correlation
The objective of this study was to develop a new approach for fabrication of zero order
release of active pharmaceutical ingredients (APIs) using hot-melt extrusion (HME) and 3D …
release of active pharmaceutical ingredients (APIs) using hot-melt extrusion (HME) and 3D …
Characterization of amorphous solid dispersions: An update
X Ma, RO Williams III - Journal of Drug Delivery Science and Technology, 2019 - Elsevier
Amorphous solid dispersions (ASDs) are a promising formulation approach to improve the
solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. ASDs have …
solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. ASDs have …
Development of 3D printed tablets by fused deposition modeling using polyvinyl alcohol as polymeric matrix for rapid drug release
In this study, the processability of polyvinyl alcohol (PVA), a water-soluble polymer, into melt-
extruded filaments and then into 3D printed tablets by fused deposition modeling was …
extruded filaments and then into 3D printed tablets by fused deposition modeling was …
Development and evaluation of an oral fast disintegrating anti-allergic film using hot-melt extrusion technology
MB Pimparade, A Vo, AS Maurya, J Bae… - European Journal of …, 2017 - Elsevier
The main objective of this novel study was to develop chlorpheniramine maleate orally
disintegrating films (ODF) using hot-melt extrusion technology and evaluate the …
disintegrating films (ODF) using hot-melt extrusion technology and evaluate the …
Characterization of amorphous solid dispersions
The study of amorphous solid dispersions (ASDs) is currently one of the most exciting areas
in pharmaceutics. Research has shown that ASDs offer unique advantages in improving the …
in pharmaceutics. Research has shown that ASDs offer unique advantages in improving the …
Application and limitations of thermogravimetric analysis to delineate the hot melt extrusion chemical stability processing window
DE Moseson, MA Jordan, DD Shah, ID Corum… - International Journal of …, 2020 - Elsevier
Thermogravimetric analysis (TGA) is frequently used to define the threshold of acceptable
processing temperatures for hot melt extrusion. Herein, evaluation of chemical stability of …
processing temperatures for hot melt extrusion. Herein, evaluation of chemical stability of …
Polymer–surfactant system based amorphous solid dispersion: Precipitation inhibition and bioavailability enhancement of itraconazole
The rapid release of poorly water-soluble drugs from amorphous solid dispersion (ASD) is
often associated with the generation of supersaturated solution, which provides a strong …
often associated with the generation of supersaturated solution, which provides a strong …