Focal adhesion dynamics in cellular function and disease
YG Mishra, B Manavathi - Cellular signalling, 2021 - Elsevier
Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM),
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …
Tumor cell infiltration into the brain in glioblastoma: from mechanisms to clinical perspectives
Simple Summary The estimated survival time for glioblastoma patients is extremely low; only
about 5% of patients survive five years post diagnosis. The standard of care for glioblastoma …
about 5% of patients survive five years post diagnosis. The standard of care for glioblastoma …
Assembly and disassembly of cell matrix adhesions
B Wehrle-Haller - Current opinion in cell biology, 2012 - Elsevier
The formation of tissues and organs requires cells to adhere to each other and/or to migrate
and polarize in contact with components of the extracellular matrix. The connection between …
and polarize in contact with components of the extracellular matrix. The connection between …
STIM1- and Orai1-mediated Ca2+ oscillation orchestrates invadopodium formation and melanoma invasion
J Sun, F Lu, H He, J Shen, J Messina, R Mathew… - Journal of Cell …, 2014 - rupress.org
Ca2+ signaling has been increasingly implicated in cancer invasion and metastasis, and
yet, the underlying mechanisms remained largely unknown. In this paper, we report that …
yet, the underlying mechanisms remained largely unknown. In this paper, we report that …
[HTML][HTML] A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the …
RE Kast, JA Boockvar, A Brüning, F Cappello… - Oncotarget, 2013 - ncbi.nlm.nih.gov
To improve prognosis in recurrent glioblastoma we developed a treatment protocol based
on a combination of drugs not traditionally thought of as cytotoxic chemotherapy agents but …
on a combination of drugs not traditionally thought of as cytotoxic chemotherapy agents but …
NaV1.5 Na+ channels allosterically regulate the NHE-1 exchanger and promote the activity of breast cancer cell invadopodia
The degradation of the extracellular matrix by cancer cells represents an essential step in
metastatic progression and this is performed by cancer cell structures called invadopodia …
metastatic progression and this is performed by cancer cell structures called invadopodia …
TNF-α promotes breast cancer cell migration and enhances the concentration of membrane-associated proteases in lipid rafts
D Wolczyk, M Zaremba-Czogalla… - Cellular Oncology, 2016 - Springer
Purpose Tumor progression is associated with cell migration, invasion and metastasis.
These processes are accompanied by the activation of specific proteases that are either …
These processes are accompanied by the activation of specific proteases that are either …
Pathological roles of invadopodia in cancer invasion and metastasis
H Yamaguchi - European journal of cell biology, 2012 - Elsevier
Invadopodia are actin-rich membrane protrusions formed by invasive cancer cells.
Invadopodia mediate the focal degradation of pericellular extracellular matrix (ECM) by the …
Invadopodia mediate the focal degradation of pericellular extracellular matrix (ECM) by the …
[HTML][HTML] Invadopodia: clearing the way for cancer cell invasion
K Augoff, A Hryniewicz-Jankowska… - Annals of translational …, 2020 - ncbi.nlm.nih.gov
The invasive nature of many cancer cells involves the formation of F-actin-based, lipid-raft-
enriched membrane protrusions known as invadopodia or, more broadly, invadosomes …
enriched membrane protrusions known as invadopodia or, more broadly, invadosomes …
Cell membrane fluid–mosaic structure and cancer metastasis
GL Nicolson - Cancer research, 2015 - AACR
Cancer cells are surrounded by a fluid–mosaic membrane that provides a highly dynamic
structural barrier with the microenvironment, communication filter and transport, receptor and …
structural barrier with the microenvironment, communication filter and transport, receptor and …