Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM),
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …

Simple Summary The estimated survival time for glioblastoma patients is extremely low; only
about 5% of patients survive five years post diagnosis. The standard of care for glioblastoma …

The formation of tissues and organs requires cells to adhere to each other and/or to migrate
and polarize in contact with components of the extracellular matrix. The connection between …

Ca2+ signaling has been increasingly implicated in cancer invasion and metastasis, and
yet, the underlying mechanisms remained largely unknown. In this paper, we report that …

To improve prognosis in recurrent glioblastoma we developed a treatment protocol based
on a combination of drugs not traditionally thought of as cytotoxic chemotherapy agents but …

The degradation of the extracellular matrix by cancer cells represents an essential step in
metastatic progression and this is performed by cancer cell structures called invadopodia …

Purpose Tumor progression is associated with cell migration, invasion and metastasis.
These processes are accompanied by the activation of specific proteases that are either …

Invadopodia are actin-rich membrane protrusions formed by invasive cancer cells.
Invadopodia mediate the focal degradation of pericellular extracellular matrix (ECM) by the …

The invasive nature of many cancer cells involves the formation of F-actin-based, lipid-raft-
enriched membrane protrusions known as invadopodia or, more broadly, invadosomes …

Cancer cells are surrounded by a fluid–mosaic membrane that provides a highly dynamic
structural barrier with the microenvironment, communication filter and transport, receptor and …