Regulation of the human papillomavirus lifecyle through post-translational modifications of the viral E2 protein
L Jose, T Gilson, EJ Androphy, M DeSmet - Pathogens, 2021 - mdpi.com
The human papillomavirus (HPV) is a DNA tumor virus that infects cutaneous and mucosal
epithelia where high-risk (HR) HPV infections lead to cervical, oropharyngeal, and …
epithelia where high-risk (HR) HPV infections lead to cervical, oropharyngeal, and …
BRD4S interacts with viral E2 protein to limit human papillomavirus late transcription
A Yigitliler, J Renner, C Simon, M Schneider… - Journal of …, 2021 - Am Soc Microbiol
The E2 protein encoded by human papillomaviruses (HPV) is a sequence-specific DNA-
binding protein that recruits viral and cellular proteins. Bromodomain-containing protein 4 …
binding protein that recruits viral and cellular proteins. Bromodomain-containing protein 4 …
Functions of papillomavirus E8^ E2 proteins in tissue culture and in vivo
F Kuehner, F Stubenrauch - Viruses, 2022 - mdpi.com
Papillomaviruses (PV) replicate in undifferentiated keratinocytes at low levels and to high
levels in differentiated cells. The restricted replication in undifferentiated cells is mainly due …
levels in differentiated cells. The restricted replication in undifferentiated cells is mainly due …
Phosphorylation of a conserved tyrosine in the papillomavirus E2 protein regulates Brd4 binding and viral replication
The papillomavirus (PV) E2 protein coordinates viral transcription and genome replication.
Following a strategy to identify amino acids in E2 that are posttranslationally modified, we …
Following a strategy to identify amino acids in E2 that are posttranslationally modified, we …
Focal Adhesion Kinase Binds to the HPV E2 Protein to Regulate Initial Replication after Infection
L Jose, J Gonzalez, E Kessinger, EJ Androphy… - Pathogens, 2023 - mdpi.com
Human papillomaviruses are small DNA tumor viruses that infect cutaneous and mucosal
epithelia. The viral lifecycle is linked to the differentiation status of the epithelium. During …
epithelia. The viral lifecycle is linked to the differentiation status of the epithelium. During …
Kinase activity of fibroblast growth factor receptor 3 regulates activity of the papillomavirus E2 protein
F Xie, M DeSmet, S Kanginakudru, L Jose… - Journal of …, 2017 - Am Soc Microbiol
The papillomavirus (PV) E2 protein is a DNA binding, protein interaction platform that
recruits viral and host factors necessary for transcription and replication. We recently …
recruits viral and host factors necessary for transcription and replication. We recently …
Discovery and biological evaluation of novel dual PTP1B and ACP1 inhibitors for the treatment of insulin resistance
B Feng, J Zhang, Z Liu, Y Xu, H Hu - Bioorganic & Medicinal Chemistry, 2024 - Elsevier
In this study, a virtual screening pipeline comprising ligand-based and structure-based
approaches was established and applied for the identification of dual PTP1B and ACP1 …
approaches was established and applied for the identification of dual PTP1B and ACP1 …
Phosphorylation of the human papillomavirus E2 protein at tyrosine 138 regulates episomal replication
L Jose, EJ Androphy, M DeSmet - Journal of Virology, 2020 - Am Soc Microbiol
The papillomavirus (PV) E2 protein is a critical regulator of viral transcription and genome
replication. We previously reported that tyrosine (Y) 138 of HPV-31 E2 is phosphorylated by …
replication. We previously reported that tyrosine (Y) 138 of HPV-31 E2 is phosphorylated by …
Identification and functional characterization of phosphorylation sites of the human papillomavirus 31 E8^ E2 protein
S van de Poel, M Dreer, A Velic, B Macek… - Journal of …, 2018 - Am Soc Microbiol
The papillomavirus E2 protein regulates transcription, replication, and nuclear retention of
viral genomes. Phosphorylation of E2 in the hinge region has been suggested to modulate …
viral genomes. Phosphorylation of E2 in the hinge region has been suggested to modulate …
[HTML][HTML] Papillomavirus E2 protein is regulated by specific fibroblast growth factor receptors
M DeSmet, S Kanginakudru, L Jose, F Xie, T Gilson… - Virology, 2018 - Elsevier
The papillomavirus (PV) E2 protein activates transcription and replication by recruiting
cellular proteins and the E1 DNA helicase to their binding sites in the viral genome. We …
cellular proteins and the E1 DNA helicase to their binding sites in the viral genome. We …