Although oral drug delivery is the preferred administration route and has been used for
centuries, modern drug discovery and development pipelines challenge conventional …

Model-informed precision dosing (MIPD) has become synonymous with modern approaches
for individualizing drug therapy, in which the characteristics of each patient are considered …

Neurodegenerative diseases (NDs) are characterised by progressive dysfunction of
synapses, neurons, glial cells and their networks. Neurodegenerative diseases can be …

Variability in individual capacity for hepatic elimination of therapeutic drugs is well
recognized and is associated with variable expression and activity of liver enzymes and …

The effect of membrane transporters on drug disposition, efficacy and safety is now well
recognized. Since the initial publication from the International Transporter Consortium …

Organs-on-a-Chip (OOAC) is a disruptive technology with widely recognized potential to
change the efficiency, effectiveness, and costs of the drug discovery process; to advance …

The liver has a wide range of physiological functions in the body, and its health is
maintained by complex cross-talk among hepatic cells, including parenchymal hepatocytes …

Liver‐derived small extracellular vesicles (sEVs), prepared from small sets of banked serum
samples using a novel two‐step protocol, were deployed as liquid biopsy to study the …

Pharmacogenomics (PGx) enables personalized treatment for the prediction of drug
response and to avoid adverse drug reactions. Currently, PGx mainly relies on the genetic …

A reliable translation of in vitro and preclinical data on drug absorption, distribution,
metabolism, and excretion (ADME) to humans is important for safe and effective drug …