Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) senses misplaced genomic,
mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2′ 3′-cGAMP …

Innate immunity is essential for the host against pathogens, cancer, and autoimmunity. The
innate immune system encodes many sensor, adaptor, and effector proteins and relies on …

Heterozygous missense mutations in coatomer protein subunit α, COPA, cause a syndrome
overlapping clinically with type I IFN-mediated disease due to gain-of-function in STING, a …

DNA-induced liquid-liquid phase separation of cyclic GMP-AMP synthase (cGAS) triggers a
potent response to detect pathogen infection and promote innate immune signaling …

Mitochondrial DNA (mtDNA) has been suggested to drive immune system activation, but the
induction of interferon signaling by mtDNA has not been demonstrated in a Mendelian …

Cell‐autonomous sensing of nucleic acids is essential for host defence against invading
pathogens by inducing antiviral and inflammatory cytokines. cGAS has emerged in recent …

Within the cytoplasm of mammalian cells is a protein called cyclic GMP‐AMP synthase
(cGAS), which acts to defend against infection and other threats to the host. cGAS operates …

The highly prevalent herpes simplex virus type 1 (HSV-1) causes a range of diseases,
including cold sores, blinding keratitis, and life-threatening encephalitis. HSV-1 initially …

Host proteins sense viral products and induce defence mechanisms, particularly in immune
cells. Using cell-free assays and quantitative mass spectrometry, we determined the …

Spatiotemporal separation of cellular components is vital to ensure biochemical processes.
Membrane-bound organelles such as mitochondria and nuclei play a major role in isolating …