Scorpion venom as a source of antimicrobial peptides: overview of biomolecule separation, analysis and characterization methods

S Nasr, A Borges, C Sahyoun, R Nasr, R Roufayel… - Antibiotics, 2023 - mdpi.com
Scorpion venoms have long captivated scientific researchers, primarily due to the potency
and specificity of the mechanism of action of their derived components. Among other …

A critical review of short antimicrobial peptides from scorpion venoms, their physicochemical attributes, and potential for the development of new drugs

PA Fong-Coronado, V Ramirez… - The Journal of …, 2024 - Springer
Scorpion venoms have proven to be excellent sources of antimicrobial agents. However,
although many of them have been functionally characterized, they remain underutilized as …

Enlightening the toxinological dark matter of spider venom enzymes

J Dresler, V Herzig, A Vilcinskas, T Lüddecke - npj Biodiversity, 2024 - nature.com
Spiders produce highly adapted venoms featuring a complex mixture of biomolecules used
mainly for hunting and defense. The most prominent components are peptidic neurotoxins, a …

Venomics of Leiurus abdullahbayrami, the most lethal scorpion in the Levant region of the Middle East

A Borges, B Lomonte - Toxicon, 2024 - Elsevier
The scorpion Leiurus abdullahbayrami has been associated with severe/lethal
envenomings throughout the Levant region of the Middle East, encompassing Turkey, Syria …

Genome-wide identification, structural homology analysis, and evolutionary diversification of the phospholipase D gene family in the venom gland of three scorpion …

M Baradaran, F Salabi - BMC genomics, 2023 - Springer
Abstract Background Venom phospholipase D (PLDs), dermonecrotic toxins like, are the
major molecules in the crude venom of scorpions, which are mainly responsible for lethality …

Varying Modes of Selection Among Toxin Families in the Venoms of the Giant Desert Hairy Scorpions (Hadrurus)

GS Nystrom, SA Ellsworth, MJ Ward… - Journal of Molecular …, 2023 - Springer
Venoms are primarily believed to evolve under strong diversifying selection resulting from
persistent coevolution between predator and prey. Recent research has challenged this …

A roadmap to the enzymes from spider venom: Biochemical ecology, molecular diversity, and value for the bioeconomy

J Dresler, I Avella, M Damm, L Dersch… - Frontiers in Arachnid …, 2024 - frontiersin.org
Spiders are ancient and highly successful predators, which use venom for both predation
and defense. Their venoms are complex mixtures of potent biological molecules, emerging …

Mass spectrometric analysis of Odonthobuthus Doriae scorpion venom and its non-neutralized fractions after interaction with commercial antivenom

A Abdollahnia, K Bahmani, A Aliahmadi, MA As' habi… - Scientific Reports, 2024 - nature.com
It is believed that antivenoms play a crucial role in neutralizing venoms. However,
uncontrolled clinical effects appear in patients stung by scorpions after the injection of …

Proteomic Analysis of Heloderma horridum horridum Venom: Assessment to Its Transcriptome and Newfound Proteins

GJ Lino-López, E Ruiz-May… - Journal of Proteome …, 2024 - ACS Publications
Heloderma horridum horridum, a venomous reptile native to America, has a venom with
potential applications in treating type II diabetes. In this work, H. h. horridum venom was …

[HTML][HTML] ScorpDb: A Novel Open-Access Database for Integrative Scorpion Toxinology

M Baradaran, F Salabi, M Mahdavinia, E Mohammadi… - Toxins, 2024 - mdpi.com
Scorpion stings are a significant public health concern globally, particularly in tropical and
subtropical regions. Scorpion venoms contain a diverse array of bioactive peptides, and …