Eukaryotic cells are exquisitely responsive to external and internal cues, achieving precise
control of seemingly diverse growth processes through a complex interplay of regulatory …

Phosphatidylserine (PS) is a negatively charged phospholipid that displays a highly uneven
distribution within cellular membranes, essential for establishment of cell polarity and other …

P4 ATPase lipid flippases are ATP-driven transporters that translocate specific lipids from
the exoplasmic to the cytosolic leaflet of biological membranes, thus establishing a lipid …

Sterols are important lipid components of the plasma membrane (PM) in eukaryotic cells, but
it is unknown how the PM retains sterols at a high concentration. Phospholipids are …

P4 ATPases are active membrane transporters that translocate lipids towards the cytosolic
side of the biological membranes in eukaryotic cells. Due to their essential cellular functions …

The lipid bilayer of biological membranes has a complex composition, including high
chemical heterogeneity, the presence of nanodomains of specific lipids, and asymmetry with …

As first demonstrated in budding yeast (Saccharomyces cerevisiae), all eukaryotic cells
contain two, distinct multi-component protein kinase complexes that each harbor the TOR …

Lipid flippases (P4 ATPases) are active transporters that catalyse the translocation of lipids
between the two sides of the biological membranes in the secretory pathway. This activity …

Candida albicans is a common cause of human mucosal yeast infections, and invasive
candidiasis can be fatal. Antifungal medications are limited, but those targeting the pathogen …

P4‐ATPases in complex with Cdc50 subunits are lipid flippases that couple ATP hydrolysis
with lipid transport to the cytoplasmic leaflet of membranes to create lipid asymmetry. Such …