Inflammation and oxidative stress in multiple sclerosis: consequences for therapy development

V Pegoretti, KA Swanson, JR Bethea… - Oxidative medicine …, 2020 - Wiley Online Library
CNS inflammation is a major driver of MS pathology. Differential immune responses,
including the adaptive and the innate immune system, are observed at various stages of MS …

Epidemiology, diagnosis and management of sexual dysfunction in multiple sclerosis

J Drulovic, D Kisic-Tepavcevic, T Pekmezovic - Acta Neurologica Belgica, 2020 - Springer
Multiple sclerosis (MS) is the most common chronic neurological disorder in young adults,
with numerous potential effects on neurologic function. Sexual dysfunction (SD) is a …

[HTML][HTML] Pain in people with multiple sclerosis: associations with modifiable lifestyle factors, fatigue, depression, anxiety, and mental health quality of life

CH Marck, AM De Livera, TJ Weiland… - Frontiers in …, 2017 - frontiersin.org
Background People with multiple sclerosis (MS) often experience pain, which can interfere
with mobility, employment, and quality of life (QOL). Methods This cross-sectional study …

Regulatory T cells and their derived cytokine, interleukin-35, reduce pain in experimental autoimmune encephalomyelitis

SS Duffy, BA Keating, CJ Perera, JG Lees… - Journal of …, 2019 - Soc Neuroscience
Sensory problems such as neuropathic pain are common and debilitating symptoms in
multiple sclerosis (MS), an autoimmune inflammatory disorder of the CNS. Regulatory T …

Endoplasmic reticulum stress in the dorsal root ganglia regulates large‐conductance potassium channels and contributes to pain in a model of multiple sclerosis

MS Yousuf, S Samtleben, SM Lamothe… - The FASEB …, 2020 - Wiley Online Library
Neuropathic pain is a common symptom of multiple sclerosis (MS) and current treatment
options are ineffective. In this study, we investigated whether endoplasmic reticulum (ER) …

Fingolimod reduces neuropathic pain behaviors in a mouse model of multiple sclerosis by a sphingosine-1 phosphate receptor 1-dependent inhibition of central …

S Doolen, T Iannitti, RR Donahue, BC Shaw… - Pain, 2018 - journals.lww.com
Multiple sclerosis (MS) is an autoimmune-inflammatory neurodegenerative disease that is
often accompanied by a debilitating neuropathic pain. Disease-modifying agents slow down …

[HTML][HTML] Peripheral and central neuroinflammatory changes and pain behaviors in an animal model of multiple sclerosis

SS Duffy, CJ Perera, PGS Makker, JG Lees… - Frontiers in …, 2016 - frontiersin.org
Pain is a widespread and debilitating symptom of multiple sclerosis (MS), a chronic
inflammatory demyelinating disease of the central nervous system. Although central …

Impact of multiple sclerosis on male sexual and reproductive health

H Geng, Q Ye, X Lin, S Simpson-Yap, Y Zhou… - Multiple Sclerosis and …, 2023 - Elsevier
Multiple sclerosis (MS) is a chronic inflammatory and autoimmune neurodegenerative
disease characterized by the destruction of myelin in the central nervous system, leading to …

Central amygdala inflammation drives pain hypersensitivity and attenuates morphine analgesia in experimental autoimmune encephalomyelitis

Z Dworsky-Fried, CA Faig, HA Vogel, BJ Kerr… - Pain, 2022 - journals.lww.com
Chronic pain is a highly prevalent symptom associated with the autoimmune disorder
multiple sclerosis (MS). The central nucleus of the amygdala plays a critical role in pain …

Pharmacological and Non-pharmacological Approaches for the Management of Neuropathic Pain in Multiple Sclerosis

AD Shkodina, M Bardhan, H Chopra, OE Anyagwa… - CNS drugs, 2024 - Springer
Multiple sclerosis is a chronic inflammatory disease that affects the central nervous system
and can cause various types of pain including ongoing extremity pain, Lhermitte's …