Blood-brain barrier integrity and glial support: mechanisms that can be targeted for novel therapeutic approaches in stroke
PT Ronaldson, TP Davis - Current pharmaceutical design, 2012 - ingentaconnect.com
The blood-brain barrier (BBB) is a critical regulator of brain homeostasis. Additionally, the
BBB is the most significant obstacle to effective CNS drug delivery. It possesses specific …
BBB is the most significant obstacle to effective CNS drug delivery. It possesses specific …
Implications of post-recanalization perfusion deficit after acute ischemic stroke: a scoping review of clinical and preclinical imaging studies
N van der Knaap, BAA Franx, CBLM Majoie… - Translational Stroke …, 2024 - Springer
The goal of reperfusion therapy for acute ischemic stroke (AIS) is to restore cerebral blood
flow through recanalization of the occluded vessel. Unfortunately, successful recanalization …
flow through recanalization of the occluded vessel. Unfortunately, successful recanalization …
Postischemic hyperperfusion on arterial spin labeled perfusion MRI is linked to hemorrhagic transformation in stroke
S Yu, DS Liebeskind, S Dua… - Journal of Cerebral …, 2015 - journals.sagepub.com
The purpose of this study was to investigate the relationship between hyperperfusion and
hemorrhagic transformation (HT) in acute ischemic stroke (AIS). Pseudo-continuous arterial …
hemorrhagic transformation (HT) in acute ischemic stroke (AIS). Pseudo-continuous arterial …
Hyperperfusion profiles after recanalization differentially associate with outcomes in a rat ischemic stroke model
BAA Franx, GAF Van Tilborg, A Taha… - Journal of Cerebral …, 2024 - journals.sagepub.com
Futile recanalization hampers prognoses of ischemic stroke after successful mechanical
thrombectomy, hypothetically through post-recanalization perfusion deficits, onset-to-groin …
thrombectomy, hypothetically through post-recanalization perfusion deficits, onset-to-groin …
Multiparametric, longitudinal optical coherence tomography imaging reveals acute injury and chronic recovery in experimental ischemic stroke
Progress in experimental stroke and translational medicine could be accelerated by high-
resolution in vivo imaging of disease progression in the mouse cortex. Here, we introduce …
resolution in vivo imaging of disease progression in the mouse cortex. Here, we introduce …
Transient selective brain cooling confers neurovascular and functional protection from acute to chronic stages of ischemia/reperfusion brain injury
J Zhao, H Mu, L Liu, X Jiang, D Wu… - Journal of Cerebral …, 2019 - journals.sagepub.com
Ischemic injury can be alleviated by the judicious use of hypothermia. However, the optimal
regimens and the temporal kinetics of post-stroke neurovascular responses to hypothermic …
regimens and the temporal kinetics of post-stroke neurovascular responses to hypothermic …
Magnetic resonance imaging of blood–brain barrier permeability in ischemic stroke using diffusion-weighted arterial spin labeling in rats
YV Tiwari, J Lu, Q Shen, B Cerqueira… - Journal of Cerebral …, 2017 - journals.sagepub.com
Diffusion-weighted arterial spin labeling magnetic resonance imaging has recently been
proposed to quantify the rate of water exchange (Kw) across the blood–brain barrier in …
proposed to quantify the rate of water exchange (Kw) across the blood–brain barrier in …
Stroke-induced damage on the blood–brain barrier
S Xue, X Zhou, ZH Yang, XK Si, X Sun - Frontiers in Neurology, 2023 - frontiersin.org
The blood–brain barrier (BBB) is a functional phenotype exhibited by the neurovascular unit
(NVU). It is maintained and regulated by the interaction between cellular and non-cellular …
(NVU). It is maintained and regulated by the interaction between cellular and non-cellular …
Neuroprotective efficacy of methylene blue in ischemic stroke: an MRI study
Methylene blue (MB) has unique energy-enhancing and antioxidant properties and is FDA-
approved drug to treat methemoglobinemia and cyanide poisoning. This study evaluated the …
approved drug to treat methemoglobinemia and cyanide poisoning. This study evaluated the …
The effects of methylene blue on autophagy and apoptosis in MRI-defined normal tissue, ischemic penumbra and ischemic core
Methylene blue (MB) USP, which has energy-enhancing and antioxidant properties, is
currently used to treat methemoglobinemia and cyanide poisoning in humans. We recently …
currently used to treat methemoglobinemia and cyanide poisoning in humans. We recently …