The budding yeast Saccharomyces cerevisiae has been the principal organism used in
experiments to examine genetic recombination in eukaryotes. Studies over the past decade …

The DNA double-strand break (DSB) is the principle cytotoxic lesion for ionizing radiation
and radio-mimetic chemicals but can also be caused by mechanical stress on chromosomes …

The SIR genes are determinants of life span in yeast mother cells. Here we show that life
span regulation by the Sir proteins is independent of their role in nonhomologous end …

Eukaryotic cells repair DNA double‐strand breaks (DSBs) by at least two pathways,
homologous recombination (HR) and non‐homologous end‐joining (NHEJ). Rad54 …

Mutations in the Artemis protein in humans result in hypersensitivity to DNA double-strand
break-inducing agents and absence of B and T lymphocytes (radiosensitive severe …

Ku is an abundant, highly conserved DNA binding protein found in both prokaryotes and
eukaryotes that plays essential roles in the maintenance of genome integrity. In eukaryotes …

Non-homologous DNA end-joining (NHEJ)—the main pathway for repairing double-
stranded DNA breaks—functions throughout the cell cycle to repair such lesions. Defects in …

Abstract The V (D) J recombination process insures the somatic diversification of
immunoglobulin and antigen T cell receptor encoding genes. This reaction is initiated by a …

▪ Abstract The process of homologous recombination promotes error-free repair of double-
strand breaks and is essential for meiosis. Central to the process of homologous …

The DNA-dependent protein kinase (DNA–PK) is a nuclear serine/threonine protein kinase
that is activated upon association with DNA. Biochemical and genetic data have revealed …