OBJECTIVE: While trazodone is approved for the treatment of depression, the off-label use
of this medication for insomnia has surpassed its usage as an antidepressant. In this …

Trazodone is a triazolopyridine derivative that belongs to the class of serotonin receptor
antagonists and reuptake inhibitors (SARIs). The drug is approved and marketed in several …

Trazodone has been widely prescribed for off-label use as a sleep aid. Identifying how
trazodone impacts the performance of polysomnographic sleep architecture in insomnia …

This study aims to explore the comparative efficacy and acceptability of psychotherapies,
pharmacotherapies, and their combinations for insomnia. MEDLINE, EMBASE, Cochrane …

The aim of this review was to describe the sleep anomalies in depression, the effects of
antidepressants on sleep, the usefulness of antidepressants in the treatment of primary …

Study Objectives: The insomnia with objective short sleep duration phenotype is associated
with increased risk for adverse health outcomes, physiological hyperarousal, and a blunted …

Background Sleep disturbances are seen even in individuals on opioid agonist treatment
(OAT). Established pharmacotherapy for sleep disturbances such as benzodiazepines have …

Sedative antidepressants are commonly used drugs in the treatment of insomnia. However,
some recommendations claim that only hypnotics have been proven effective in the …

Introduction: Gamma-hydroxybutyrate (GHB) is a short-chain fatty acid that is synthesized
within the CNS, mostly from its parent compound gamma amino butyric acid (GABA). GHB …

The purpose of the present paper is to review and summarize the research supporting
nonpharmacologic treatment options for insomnia. The different treatment approaches are …