Tight junction proteins and the biology of hepatobiliary disease

N Roehlen, AA Roca Suarez, H El Saghire… - International journal of …, 2020 - mdpi.com
Tight junctions (TJ) are intercellular adhesion complexes on epithelial cells and composed
of integral membrane proteins as well as cytosolic adaptor proteins. Tight junction proteins …

[HTML][HTML] Influence of genetic and environmental risk factors in the development of hepatocellular carcinoma in Mexico

LE Gomez-Quiroz, S Roman - Annals of Hepatology, 2022 - Elsevier
The latest studies on the epidemiology of diverse types of cancers have located in the scene
the relevance of liver tumors, particularly hepatocellular carcinoma (HCC). HCC is a life …

GDF-11 promotes human trophoblast cell invasion by increasing ID2-mediated MMP2 expression

Z Wu, L Fang, S Yang, Y Gao, Z Wang, Q Meng… - Cell Communication and …, 2022 - Springer
Background Growth differentiation factor-11 (GDF-11), also known as bone morphogenetic
protein-11, belongs to the transforming growth factor-beta superfamily. GDF-11 was first …

[HTML][HTML] GDF11 as a friend or an enemy in the cancer biology?

W Król, W Machelak, M Zielińska - … et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Abstract The Growth and Differential Factor 11 (GDF11) is a recently discovered
representative of Transforming Growth Factor β superfamily. The highest expression of …

[HTML][HTML] GDF11 rapidly increases lipid accumulation in liver cancer cells through ALK5-dependent signaling

J Frohlich, T Mazza, C Sobolewski, M Foti… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Hepatocellular carcinoma (HCC) is one of the fastest-growing causes of cancer-related
mortalities worldwide and this trend is mimicked by the surge of non-alcoholic fatty liver …

The regulatory effect of growth differentiation factor 11 on different cells

Y Shao, T Liu, X Wen, R Zhang, X Liu… - Frontiers in …, 2023 - frontiersin.org
Growth differentiation factor 11 (GDF11) is one of the important factors in the
pathophysiological process of animals. It is widely expressed in many tissues and organs of …

[HTML][HTML] Growth differentiation factor 11: a “rejuvenation factor” involved in regulation of age-related diseases?

Y Ma, Y Liu, F Han, H Qiu, J Shi, N Huang… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Abstract Growth differentiation factor 11 (GDF11), a member of the transforming growth
factor β superfamily of cytokines, is a critical rejuvenation factor in aging cells. GDF11 …

GDF11 implications in cancer biology and metabolism. Facts and controversies

A Simoni-Nieves, M Gerardo-Ramírez… - Frontiers in …, 2019 - frontiersin.org
Growth Differentiation Factor 11 (GDF11), a member of the super family of the Transforming
Growth Factor β, has gained more attention in the last few years due to numerous reports …

The hepatic effects of GDF11 on health and disease

M Gerardo-Ramírez, N German-Ramirez… - Biochimie, 2023 - Elsevier
The growth differentiation factor 11 (GDF11), a member of the superfamily of the
transforming growth factor β, has gained relevance in the last few years due to its …

Exosome-transmitted miR-3124-5p promotes cholangiocarcinoma development via targeting GDF11

H Gao, Z He, C Gao, N Liu, Z Zhang, W Niu… - Frontiers in …, 2022 - frontiersin.org
Objective Cholangiocarcinoma (CHOL) is a deadly cancer worldwide with limited available
therapies. The aim of this study was to investigate key exosomal miRNAs and their functions …