The introduction of the biopharmaceutics drug classification system (Biopharmaceutics
Classification System (BCS)), in 1995, provided a simple way to describe the …

Various gastrointestinal (GI) factors affect drug and formulation behavior after oral
administration, including GI transfer, motility, pH and GI fluid volume and composition. An in …

This work provides an elaborate characterization of human intestinal fluids (HIF) collected in
fasted-and fed-state conditions. HIF from 20 healthy volunteers (10 M/F) were aspirated by …

The rate and extent of drug dissolution in the gastrointestinal (GI) tract are highly dependent
upon drug physicochemical properties and GI fluid properties. Biorelevant dissolution media …

Abstract mRNA pharmaceuticals represent a new class of therapeutics, with applications, in
cancer vaccination, tumour therapy and protein substitution. Formulations are required to …

Intestinal fluids dictate the intraluminal environment, and therefore, they substantially affect
the absorption of orally taken drugs. The characterization of human intestinal fluids (HIF) and …

Niclosamide is an FDA-approved anthelmintic that is being studied in clinical trials as a
chemotherapeutic and broad-spectrum antiviral. Additionally, several other applications are …

OrBiTo was a precompetitive collaboration focused on the development of the next
generation of Oral Biopharmaceutics Tools. The consortium included world leading …

An ideal dissolution test for amorphous solid dispersions (ASDs) should reflect
physicochemical, physiological, and hydrodynamic conditions which accurately represent in …

Nutraceuticals provide an additional health or medicinal benefit besides their nutritional
value and are therefore marketed for the prevention and treatment of certain conditions …