Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

While hormonal contraceptives are efficacious and available in several forms for women,
perception of safety and concern over side effects are a deterrent for many. Existing non …

Cytosine base editing achieves C• G-to-T• A substitutions and can convert four codons
(CAA/CAG/CGA/TGG) into STOP-codons (induction of STOP-codons, iSTOP) to knock out …

A large body of evidence indicates that women with polycystic ovary syndrome (PCOS) have
a higher risk of developing Hashimoto's thyroiditis (HT) than healthy individuals. Given the …

Oocyte quality is essential for a successful pregnancy. 1-Nitropyrene (1-NP) is a widely
distributed pollutant in the environment and is well-known for its mutagenicity and …

The oocyte must grow and mature before fertilization, thanks to a close dialogue with the
somatic cells that surround it. Part of this communication is through filopodia-like protrusions …

Sialic acids are a family of 9-carbon monosaccharides with particular physicochemical
properties. They modulate the biological functions of the molecules that carry them and are …

Long non-coding RNAs (lncRNAs) have been the subject of numerous studies over the past
decade. First thought to come from aberrant transcriptional events, lncRNAs are now …

Monospermy occurs in the process of normal fertilization where a single sperm fuses with
the egg, resulting in the formation of a diploid zygote. During the process of fertilization, the …

In oocyte biology, the zona pellucida has long been known to operate three extracellular
functions downstream of the secretory pathway, namely, encasing the oocytes in ovarian …