Expansion of Auxiliary Activity Family 5 sequence space via biochemical characterization of six new copper radical oxidases
JK Fong, Y Mathieu, MT Vo, A Bellemare… - Applied and …, 2024 - journals.asm.org
Bacterial and fungal copper radical oxidases (CROs) from Auxiliary Activity Family 5 (AA5)
are implicated in morphogenesis and pathogenesis. The unique catalytic properties of …
are implicated in morphogenesis and pathogenesis. The unique catalytic properties of …
Evolving ω-amine transaminase AtATA guided by substrate-enzyme binding free energy for enhancing activity and stability against non-natural substrates
S Qiu, CL Ju, T Wang, J Chen, YT Cui… - Applied and …, 2024 - Am Soc Microbiol
In the field of chiral amine synthesis, ω-amine transaminase (ω-ATA) is one of the most
established enzymes capable of asymmetric amination under optimal conditions. However …
established enzymes capable of asymmetric amination under optimal conditions. However …
[HTML][HTML] Rational engineering of homospermidine synthase for enhanced catalytic efficiency toward spermidine synthesis
W Liu, X Hu, Y Yan, Y Cai - Synthetic and Systems Biotechnology, 2024 - Elsevier
Spermidine is a naturally occurring polyamine widely utilized in the prevention and
treatment of various diseases. Current spermidine biosynthetic methods have problems …
treatment of various diseases. Current spermidine biosynthetic methods have problems …
A Machine Learning-Guided Approach to Navigate the Substrate Activity Scope of Galactose Oxidase: Application in the Conversion of Pharmaceutically Relevant …
Biocatalysis is increasingly being adopted in industry for producing important chemicals in a
selective, efficient, and sustainable way. Engineering an enzyme can often confer it with an …
selective, efficient, and sustainable way. Engineering an enzyme can often confer it with an …