[HTML][HTML] The impact of chromatin on double-strand break repair: Imaging tools and discoveries
MAE van Bueren, A Janssen - DNA repair, 2024 - Elsevier
Eukaryotic nuclei are constantly being exposed to factors that break or chemically modify the
DNA. Accurate repair of this DNA damage is crucial to prevent DNA mutations and maintain …
DNA. Accurate repair of this DNA damage is crucial to prevent DNA mutations and maintain …
[HTML][HTML] PCAF-mediated histone acetylation promotes replication fork degradation by MRE11 and EXO1 in BRCA-deficient cells
Stabilization of stalled replication forks is a prominent mechanism of PARP (Poly (ADP-
ribose) Polymerase) inhibitor (PARPi) resistance in BRCA-deficient tumors. Epigenetic …
ribose) Polymerase) inhibitor (PARPi) resistance in BRCA-deficient tumors. Epigenetic …
ZMYM2 restricts 53BP1 at DNA double-strand breaks to favor BRCA1 loading and homologous recombination
An inability to repair DNA double-strand breaks (DSBs) threatens genome integrity and can
contribute to human diseases, including cancer. Mammalian cells repair DSBs mainly …
contribute to human diseases, including cancer. Mammalian cells repair DSBs mainly …
Poly (ADP-ribose) binding and macroH2A mediate recruitment and functions of KDM5A at DNA lesions
The histone demethylase KDM5A erases histone H3 lysine 4 methylation, which is involved
in transcription and DNA damage responses (DDRs). While DDR functions of KDM5A have …
in transcription and DNA damage responses (DDRs). While DDR functions of KDM5A have …
[HTML][HTML] Systematic overview on the most widespread techniques for inducing and visualizing the DNA double-strand breaks
I Berzsenyi, V Pantazi, BN Borsos, T Pankotai - Mutation Research/Reviews …, 2021 - Elsevier
DNA double-strand breaks (DSBs) are one of the most frequent causes of initiating
cancerous malformations, therefore, to reduce the risk, cells have developed sophisticated …
cancerous malformations, therefore, to reduce the risk, cells have developed sophisticated …
Imaging the response to DNA damage in heterochromatin domains
A Chansard, E Pobega, P Caron… - Frontiers in Cell and …, 2022 - frontiersin.org
The eukaryotic genome is assembled in a nucleoprotein complex called chromatin, whose
organization markedly influences the repair of DNA lesions. For instance, compact …
organization markedly influences the repair of DNA lesions. For instance, compact …
[图书][B] Modulating the Activity of OGG1 Using Small Molecules to Target the Oxidative DNA Damage Response in Cancer and Inflammation
BMF Hanna - 2021 - search.proquest.com
The production of reactive oxygen species (ROS) is increased in several pathological
conditions including cancer and inflammation. Multiple lines of evidence suggest that ROS …
conditions including cancer and inflammation. Multiple lines of evidence suggest that ROS …
[PDF][PDF] Live Cell Fluorescence Imaging of Nucleotide Dynamics: ATP Hydrolysis and DNA Damage
A Bhat - 2021 - kops.uni-konstanz.de
Nukleotide sind eine Klasse von Biomolekülen, welche nicht nur als Zellbestandteil dienen,
sondern auch entscheidend für die Zellfunktion und Homöostase sind. Ein Nukleotid besteht …
sondern auch entscheidend für die Zellfunktion und Homöostase sind. Ein Nukleotid besteht …
Live Cell Fluorescence Imaging of Nucleotide Dynamics: ATP Hydrolysis and DNA Damage Response
A Bhat - 2021 - kops.uni-konstanz.de
Nucleotides are biomolecules that not only act as a cellular constituent but are also crucial
for cellular functioning and homeostasis. A nucleotide consists of a nitrogenous base, sugar …
for cellular functioning and homeostasis. A nucleotide consists of a nitrogenous base, sugar …
탈유비퀴틴화효소Usp28 의DNA 손상부위결합특성연구
유정호 - 2021 - s-space.snu.ac.kr
본 연구에서는 DNA 이중가닥 절단 부위에서 탈유비퀴틴화 효소 Usp28 의 역할을 규명하기
위해, Usp28 의 DNA 손상 부위 결합 특성과 상동재조합 (homologous recombination) 회복 …
위해, Usp28 의 DNA 손상 부위 결합 특성과 상동재조합 (homologous recombination) 회복 …