T-regulatory cells (Tregs) represent a unique subpopulation of helper T-cells by maintaining
immune equilibrium using various mechanisms. The role of T-cell receptors (TCR) in …

Adaptive immune recognition is mediated by antigen receptors on B and T cells generated
by somatic recombination during lineage development. The high level of diversity resulting …

FOXP3+ regulatory T cells (Treg cells) are a specialized population of CD4+ T cells that
restrict immune activation and are essential to prevent systemic autoimmunity. In the …

T follicular helper (Tfh) cells are fundamental for B cell selection and antibody maturation in
germinal centers. Circulating Tfh (cTfh) cells constitute a minor proportion of the CD4+ T …

Tracking how individual naive T cells from a natural TCR repertoire clonally expand,
differentiate, and make lineage choices in response to an infection has not previously been …

Human aging is associated with a profound loss of thymus productivity, yet naïve T
lymphocytes still maintain their numbers by division in the periphery for many years. The …

Adaptive immune recognition is mediated by specific interactions between heterodimeric T
cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to …

One of the feats of adaptive immunity is its ability to recognize foreign pathogens while
sparing the self. During maturation in the thymus, T cells are selected through the binding …

It is well-known that the functioning of the immune system gradually deteriorates with age,
and we are increasingly confronted with its consequences as the life expectancy of the …

T-cell receptors (TCR) mediate immune responses recognizing peptides in complex with
major histocompatibility complexes (pMHC) displayed on the surface of cells. Resolving the …