In the context of OA disease, NF-κB transcription factors can be triggered by a host of stress-
related stimuli including pro-inflammatory cytokines, excessive mechanical stress and ECM …

Transcriptional regulation contributes to the maintenance of pluripotency, self-renewal and
differentiation in embryonic cells and in stem cells. Therefore, control of gene expression at …

The family of nuclear factor-kappaB (NF-κB) transcription factors is intimately involved in the
regulation of expression of numerous genes in the setting of the inflammatory response …

Objective: To discuss the acute phase of inflammatory response with a focus on the
neutrophilic response and its role in inflammation. We discuss the relative balance between …

Joint tissues are exquisitely sensitive to their mechanical environment, and mechanical
loading may be the most important external factor regulating the development and long‐term …

Protein degradation through the ubiquitin-proteasome system is the major pathway of non-
lysosomal proteolysis of intracellular proteins. It plays important roles in a variety of …

Osteoarthritis (OA) is a joint disease that involves degeneration of articular cartilage, limited
intraarticular inflammation manifested by synovitis and changes in the subchondral bone …

Biochemistry of chondrotin sulphate• Mechanism of action of chondroitin sulphate‐Effect of
chondroitin sulphate on the chondrocyte‐Effect of chondroitin sulphate on the synovial …

Obesity is a significant risk factor for developing osteoarthritis in weight-bearing and non-
weight-bearing joints. Although the pathogenesis of obesity-associated osteoarthritis is not …

Background UC-II contains a patented form of undenatured type II collagen derived from
chicken sternum. Previous preclinical and clinical studies support the safety and efficacy of …