[HTML][HTML] Metal binding properties, stability and reactivity of zinc fingers
K Kluska, J Adamczyk, A Krężel - Coordination Chemistry Reviews, 2018 - Elsevier
Zinc fingers (ZFs) are among the most structurally diverse protein domains. They interact
with nucleic acids, other proteins and lipids to facilitate a multitude of biological processes …
with nucleic acids, other proteins and lipids to facilitate a multitude of biological processes …
Emerging protein targets for metal-based pharmaceutical agents: An update
The peculiar chemical properties of metal-based drugs impart innovative pharmacological
profiles to this class of therapeutic and diagnostic agents, most likely in relation to novel …
profiles to this class of therapeutic and diagnostic agents, most likely in relation to novel …
Interactions of anticancer Pt compounds with proteins: an overlooked topic in medicinal inorganic chemistry?
A critical discussion is presented about the possible role of Pt–protein interactions in the
mechanisms of action of platinum anticancer compounds. Although, since 40 years from its …
mechanisms of action of platinum anticancer compounds. Although, since 40 years from its …
Pt-based drugs: the spotlight will be on proteins
O Pinato, C Musetti, C Sissi - Metallomics, 2014 - academic.oup.com
Platinum-complexes represent some of the most successful groups of clinically used
anticancer drugs. Their mechanism of action relies on the formation of stable DNA adducts …
anticancer drugs. Their mechanism of action relies on the formation of stable DNA adducts …
NCp7: Targeting a multitasking protein for next-generation anti-HIV drug development part 1: Covalent inhibitors
Highlights•NCp7 plays several roles in the viral life cycle.•Covalent NCp7 inhibitors are able
to extrude the zinc from the protein.•The SAR of covalent NCp7 inhibitors is discussed.•The …
to extrude the zinc from the protein.•The SAR of covalent NCp7 inhibitors is discussed.•The …
Gold (I)-phosphine-N-heterocycles: biological activity and specific (ligand) interactions on the C-terminal HIVNCp7 zinc finger
The syntheses and the characterization by chemical analysis, 1H and 31P NMR
spectroscopy, and mass spectrometry of a series of linear triphenylphosphine gold (I) …
spectroscopy, and mass spectrometry of a series of linear triphenylphosphine gold (I) …
Gold finger formation studied by high-resolution mass spectrometry and in silico methods
High-resolution mass spectrometry and quantum mechanics/molecular mechanics studies
were employed for characterizing the formation of two gold finger (GF) domains from the …
were employed for characterizing the formation of two gold finger (GF) domains from the …
Reactive selenium species: Redox modulation, antioxidant, antimicrobial and anticancer activities
Since its discovery 200 years ago, in 1817, by Jöns Jacob Berzelius (1779–1848), the
element selenium has had a rather chequered relationship with biology and medicine, an …
element selenium has had a rather chequered relationship with biology and medicine, an …
The N-terminal zinc finger and flanking basic domains represent the minimal region of the human immunodeficiency virus type-1 nucleocapsid protein for targeting …
The human immunodeficiency virus type-1 (HIV-1) nucleocapsid (NC) protein is a
chaperone that facilitates nucleic acid conformational changes to produce the most …
chaperone that facilitates nucleic acid conformational changes to produce the most …
Enhancement of the physicochemical properties of [Pt (dien)(nucleobase)] 2+ for HIVNCp7 targeting
SD Tsotsoros, PB Lutz, AG Daniel, EJ Peterson… - Chemical …, 2017 - pubs.rsc.org
Physicochemical properties of coordination compounds can be exploited for molecular
recognition of biomolecules. The inherent π–π stacking properties of [Pt (chelate)(N-donor)] …
recognition of biomolecules. The inherent π–π stacking properties of [Pt (chelate)(N-donor)] …