Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine

CA Brandsma, M Van den Berge… - The Journal of …, 2020 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high
personal and societal burden. Exposure to toxic particles and gases, including cigarette …

The porcine lung as a potential model for cystic fibrosis

CS Rogers, WM Abraham… - … of Physiology-Lung …, 2008 - journals.physiology.org
Airway disease currently causes most of the morbidity and mortality in patients with cystic
fibrosis (CF). However, understanding the pathogenesis of CF lung disease and developing …

Genetic epidemiology of COPD (COPDGene) study design

EA Regan, JE Hokanson, JR Murphy… - COPD: Journal of …, 2011 - Taylor & Francis
Background: COPDGene is a multicenter observational study designed to identify genetic
factors associated with COPD. It will also characterize chest CT phenotypes in COPD …

SPIROMICS protocol for multicenter quantitative computed tomography to phenotype the lungs

JP Sieren, JD Newell Jr, RG Barr… - American journal of …, 2016 - atsjournals.org
Multidetector row computed tomography (MDCT) is increasingly taking a central role in
identifying subphenotypes within chronic obstructive pulmonary disease (COPD), asthma …

Relationships between airflow obstruction and quantitative CT measurements of emphysema, air trapping, and airways in subjects with and without chronic obstructive …

JD Schroeder, AS McKenzie, JA Zach… - American Journal of …, 2013 - Am Roentgen Ray Soc
OBJECTIVE. This study evaluates the relationships between quantitative CT (QCT) and
spirometric measurements of disease severity in cigarette smokers with and without chronic …

[HTML][HTML] Health impact of E-cigarettes: a prospective 3.5-year study of regular daily users who have never smoked

R Polosa, F Cibella, P Caponnetto, M Maglia… - Scientific reports, 2017 - nature.com
Although electronic cigarettes (ECs) are a much less harmful alternative to tobacco
cigarettes, there is concern as to whether long-term ECs use may cause risks to human …

Factors associated with bronchiectasis in patients with COPD

MÁ Martínez-García, JJ Soler-Cataluña, YD Sanz… - Chest, 2011 - Elsevier
Background Previous studies have shown a high prevalence of bronchiectasis in patients
with moderate to severe COPD. However, the factors associated with bronchiectasis remain …

Noninvasive imaging biomarker identifies small airway damage in severe chronic obstructive pulmonary disease

DM Vasilescu, FJ Martinez, N Marchetti… - American journal of …, 2019 - atsjournals.org
Rationale: Evidence suggests damage to small airways is a key pathologic lesion in chronic
obstructive pulmonary disease (COPD). Computed tomography densitometry has been …

Pulmonary emphysema subtypes on computed tomography: the MESA COPD study

BM Smith, JHM Austin, JD Newell Jr… - The American journal of …, 2014 - Elsevier
Background Pulmonary emphysema is divided into 3 major subtypes at autopsy:
centrilobular, paraseptal, and panlobular emphysema. These subtypes can be defined by …

A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation

CCTWGRG Barr, EA Berkowitz, F Bigazzi… - COPD: Journal of …, 2012 - Taylor & Francis
The purposes of this study were: to describe chest CT findings in normal non-smoking
controls and cigarette smokers with and without COPD; to compare the prevalence of CT …