The future of early cancer detection
A proactive approach to detecting cancer at an early stage can make treatments more
effective, with fewer side effects and improved long-term survival. However, as detection …
effective, with fewer side effects and improved long-term survival. However, as detection …
Liquid biopsy and minimal residual disease—latest advances and implications for cure
K Pantel, C Alix-Panabières - Nature Reviews Clinical Oncology, 2019 - nature.com
Liquid biopsy has been introduced as a new diagnostic concept predicated on the analysis
of circulating tumour cells (CTCs) or circulating tumour-derived factors, in particular, cell-free …
of circulating tumour cells (CTCs) or circulating tumour-derived factors, in particular, cell-free …
Extensive heterogeneity in somatic mutation and selection in the human bladder
The extent of somatic mutation and clonal selection in the human bladder remains unknown.
We sequenced 2097 bladder microbiopsies from 20 individuals using targeted (n= 1914 …
We sequenced 2097 bladder microbiopsies from 20 individuals using targeted (n= 1914 …
Current and future perspectives of liquid biopsies in genomics-driven oncology
Precision oncology seeks to leverage molecular information about cancer to improve patient
outcomes. Tissue biopsy samples are widely used to characterize tumours but are limited by …
outcomes. Tissue biopsy samples are widely used to characterize tumours but are limited by …
Circulating tumor DNA analysis in patients with cancer: American Society of Clinical Oncology and College of American Pathologists joint review
Purpose.—Clinical use of analytical tests to assess genomic variants in circulating tumor
DNA (ctDNA) is increasing. This joint review from the American Society of Clinical Oncology …
DNA (ctDNA) is increasing. This joint review from the American Society of Clinical Oncology …
RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues
INTRODUCTION Cancer genome studies have contributed to the analysis and discovery of
somatic mutations that drive cancer growth. However, studying the genetic makeup of a …
somatic mutations that drive cancer growth. However, studying the genetic makeup of a …
[HTML][HTML] How liquid biopsies can change clinical practice in oncology
G Siravegna, B Mussolin, T Venesio, S Marsoni… - Annals of …, 2019 - Elsevier
Cell-free DNA fragments are shed into the bloodstream by tumor cells. The analysis of
circulating tumor DNA (ctDNA), commonly known as liquid biopsy, can be exploited for a …
circulating tumor DNA (ctDNA), commonly known as liquid biopsy, can be exploited for a …
Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations
Mutations, the fuel of evolution, are first manifested as rare DNA changes within a population
of cells. Although next-generation sequencing (NGS) technologies have revolutionized the …
of cells. Although next-generation sequencing (NGS) technologies have revolutionized the …
Cancer-associated mutations in endometriosis without cancer
MS Anglesio, N Papadopoulos, A Ayhan… - … England Journal of …, 2017 - Mass Medical Soc
Background Endometriosis, defined as the presence of ectopic endometrial stroma and
epithelium, affects approximately 10% of reproductive-age women and can cause pelvic …
epithelium, affects approximately 10% of reproductive-age women and can cause pelvic …
[HTML][HTML] High prevalence of mutantKRAS in circulating exosome-derived DNA from early-stage pancreatic cancer patients
K Allenson, J Castillo, FA San Lucas, G Scelo… - Annals of …, 2017 - Elsevier
Background Exosomes arise from viable cancer cells and may reflect a different biology than
circulating cell-free DNA (cfDNA) shed from dying tissues. We compare exosome-derived …
circulating cell-free DNA (cfDNA) shed from dying tissues. We compare exosome-derived …