Non-steroidal anti-inflammatory drugs (NSAIDs) are used chronically to reduce pain and
inflammation in patients with arthritic conditions, and also acutely as analgesics by many …

The existing epidemiologic literature was comprehensively reviewed to retrieve all
epidemiologic studies (case control and cohort studies) that examined exposure to …

Abstract Selective COX-2 inhibitors (coxibs) are approved for the relief of acute pain and
symptoms of chronic inflammatory conditions such as osteoarthritis (OA) and rheumatoid …

Celecoxib (Celebrex®), the first cyclo-oxygenase (COX) 2-selective inhibitor (coxib) to be
introduced into clinical practice, has been available for almost a decade. It is approved in …

Rheumatic diseases (RD), such as rheumatoid arthritis, systemic lupus erythematosus,
ankylosing spondylitis, psoriatic arthritis, vasculitis, gout are associated with increase in …

Background More than one decade ago, rising cases of ischemic colitis (IC) prompted the
Federal Drug Administration to revoke alosetron's approval as treatment of irritable bowel …

Aims Previous studies have suggested that nonsteroidal anti‐inflammatory drugs (NSAIDs)
may be associated with higher cardiovascular risks. However, few have been active …

We evaluated the differences in persistence with weekly oral bisphosphonate therapy
according to the initial drug. Persistence to weekly oral preparations remains suboptimal …

Randomized controlled trials (RCTs) are the gold standard for assessing the efficacy of
drugs but not necessarily so for drug safety where inadequate power to detect either multiple …

Non steroidal anti-inflammatory drugs (NSAIDs) are amongst the most commonly prescribed
medication. Some are available over the counter and likely to be abused. The …