Heteronuclear multidimensional NMR experiments for the structure determination of proteins in solution employing pulsed field gradients
M Sattler, J Schleucher, C Griesinger - Progress in nuclear magnetic …, 1999 - Elsevier
6. 3D and 4D NOESY/ROESY experiments............................................ 146 6.1. 13C-and 15N-
edited NOESY/ROESY experiments.................................. 146 6.2. Filtered experiments for …
edited NOESY/ROESY experiments.................................. 146 6.2. Filtered experiments for …
THE USE OF 2H, 13C, 15N MULTIDIMENSIONAL NMR GTO STUDY THE STRUCTURE AND DYNAMICS OF PROTEINS
KH Gardner, LE Kay - Annual review of biophysics and …, 1998 - annualreviews.org
▪ Abstract During the past thirty years, deuterium labeling has been used to improve the
resolution and sensitivity of protein NMR spectra used in a wide variety of applications. Most …
resolution and sensitivity of protein NMR spectra used in a wide variety of applications. Most …
Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
The main protease, Mpro (or 3CLpro) in SARS-CoV-2 is a viable drug target because of its
essential role in the cleavage of the virus polypeptide. Feline infectious peritonitis, a fatal …
essential role in the cleavage of the virus polypeptide. Feline infectious peritonitis, a fatal …
Cisplatin binding sites on human albumin
Reactions of cisplatin (cis-[PtCl 2 (NH 3) 2]) with albumin are thought to play an important
role in the metabolism of this anticancer drug. They are investigated here via (i) labeling of …
role in the metabolism of this anticancer drug. They are investigated here via (i) labeling of …
Organometallic ruthenium (II) diamine anticancer complexes: arene-nucleobase stacking and stereospecific hydrogen-bonding in guanine adducts
H Chen, JA Parkinson, S Parsons… - Journal of the …, 2002 - ACS Publications
Organometallic ruthenium (II) arene anticancer complexes of the type [(η6-arene) Ru (II)(en)
Cl][PF6](en= ethylenediamine) specifically target guanine bases of DNA oligomers and form …
Cl][PF6](en= ethylenediamine) specifically target guanine bases of DNA oligomers and form …
Highly selective binding of organometallic ruthenium ethylenediamine complexes to nucleic acids: novel recognition mechanisms
H Chen, JA Parkinson, RE Morris… - Journal of the American …, 2003 - ACS Publications
We have investigated the recognition of nucleic acid derivatives by organometallic
ruthenium (II) arene anticancer complexes of the type [(η6-arene) Ru (II)(en) X] where en …
ruthenium (II) arene anticancer complexes of the type [(η6-arene) Ru (II)(en) X] where en …
A suite of triple resonance NMR experiments for the backbone assignment of 15N, 13C, 2H labeled proteins with high sensitivity
T Yamazaki, W Lee, CH Arrowsmith… - Journal of the …, 1994 - ACS Publications
A suite of NMR pulse schemes is presented for the assignment of HN, 15N, 13Ca, and 13C^
resonances in 15N, 13C, 2H labeled proteins. The experiments exploit the line narrowing of …
resonances in 15N, 13C, 2H labeled proteins. The experiments exploit the line narrowing of …
NMR investigation of RNA structure
The many important biological functions of RNA range from propagation of genetic
information to catalysis in RNA processing and protein synthesis [l]. This diverse array of …
information to catalysis in RNA processing and protein synthesis [l]. This diverse array of …
Comparison of the backbone dynamics of a folded and an unfolded SH3 domain existing in equilibrium in aqueous buffer
NA Farrow, O Zhang, JD Forman-Kay, LE Kay - Biochemistry, 1995 - ACS Publications
Two-dimensional NMR 15N relaxation studies have been used to characterize the
backbone dynamics and folding transition of the N-terminal SH3 domain of the protein drk …
backbone dynamics and folding transition of the N-terminal SH3 domain of the protein drk …
Single transition-to-single transition polarization transfer (ST2-PT) in [15N, 1H]-TROSY
KV Pervushin, G Wider, K Wüthrich - Journal of biomolecular NMR, 1998 - Springer
This paper describes the use of single transition-to-single transition polarization transfer
(ST2-PT) in transverse relaxation-optimized spectroscopy (TROSY), where it affords a\sqrt 2 …
(ST2-PT) in transverse relaxation-optimized spectroscopy (TROSY), where it affords a\sqrt 2 …