We provide a comprehensive update on mitochondrial medicine therapies based on current
evidence and our single-center clinical experience to support or refute their use, and provide …

The endogenous disulfide α-lipoic acid (LA) is an essential mitochondrial co-factor. In
addition, LA and its reduced counterpart dihydro lipoic acid form a potent redox couple with …

Alzheimer's disease (AD) is a neurodegenerative disorder characterised by impairments in
the cognitive domains associated with orientation, recording, and memory. This pathology …

Lipoic acid (LA) is globally known and its supplements are widely used. Despite its
importance for the organism it is not considered a vitamin any more. The multiple metabolic …

Lipoic acid (LA) is an endogenous antioxidant that exists widely in nature. Supplementation
with LA is a promising approach to improve the outcomes of patients with multiple sclerosis …

α-Lipoic acid (ALA) is a naturally occurring sulfur-containing fatty acid with high antioxidant
activity. It is also used to treat diabetes, nerve pain, weight loss, heart disease, and primary …

The human sodium-dependent multivitamin transporter (hSMVT) is a product of the SLC5A6
gene and mediates biotin, pantothenic acid, and lipoate uptake in a variety of cellular …

Lipoic acid-modified proteins are essential for central metabolism and pathogenesis. In
recent years, the Escherichia coli and Bacillus subtilis lipoyl assembly pathways have been …

Background: α-Lipoic acid (LA) is a dietary supplement for maintaining energy balance, but
well-controlled clinical trials in otherwise healthy, overweight adults using LA …

Neurodegenerative disorders are linked to oxidative tissue damage characterized by
gradual loss of cognitive functions and neuronal cells. Alpha-lipoic acid (AHA) has a strong …