Treatment of older adult patients with glioblastoma: Moving towards the inclusion of a comprehensive geriatric assessment for guiding management

M Chahal, B Thiessen, C Mariano - Current oncology, 2022 - mdpi.com
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, and over
half of patients with newly diagnosed GBM are over the age of 65. Management of …

Frailty in geriatric glioblastoma patients: a predictor of operative morbidity and outcome

M Cloney, R D'Amico, J Lebovic, M Nazarian… - World neurosurgery, 2016 - Elsevier
Background Frailty is an emerging means of assessing overall health status and guiding
management for geriatric patients. Frailty is associated with outcomes for many surgical …

Reoperation for recurrent glioblastoma and its association with survival benefit

PA Tully, AJ Gogos, C Love, D Liew, KJ Drummond… - …, 2016 - journals.lww.com
BACKGROUND: Glioblastoma is the most common and aggressive primary brain tumor.
Despite current treatment, recurrence is inevitable. There are no clear guidelines for …

Geriatric brain tumor management part I: Meningioma

O Cohen-Inbar - Journal of Clinical Neuroscience, 2019 - Elsevier
Life expectancy continues to rise exponentially. The concept of frailty has emerged as a tool
helping to gauge overall health status and risk of adverse events in aging patients, has …

Surgical resection of glioblastoma in the very elderly: An analysis of survival outcomes using the surveillance, epidemiology, and end results database

MA Horowitz, A Ghadiyaram, Y Mehkri… - Clinical Neurology and …, 2024 - Elsevier
Objective Patients with glioblastoma (GBM) often undergo surgery to prolong survival.
However, the use of surgery, and more specifically achieving gross total resection (GTR), in …

Glioblastoma in the elderly: treatment patterns and survival

JA Pretanvil, IQ Salinas, DE Piccioni - CNS oncology, 2017 - Taylor & Francis
Aim: The optimal treatment for elderly glioblastoma patients is unclear. We conducted a
retrospective review of the California Cancer Registry to examine treatment patterns and …

Role of multidimensional assessment of frailty in predicting outcomes in older patients with glioblastoma treated with adjuvant concurrent chemo-radiation

L Giaccherini, M Galaverni, I Renna, G Timon… - Journal of Geriatric …, 2019 - Elsevier
Background Our aim was to evaluate the impact of comorbidities, clinical and biological
factors on outcomes in elderly GBM patients treated with surgery followed by concurrent …

Validation of effectiveness of keyhole clipping in nonfrail elderly patients with unruptured intracranial aneurysms

K Mori, K Wada, N Otani, A Tomiyama, T Toyooka… - Journal of …, 2017 - thejns.org
OBJECTIVE Advanced age is known to be associated with a poor prognosis after surgical
clipping of unruptured intracranial aneurysms (UIAs). Keyhole clipping techniques have …

Variable screening and model construction for prognosis of elderly patients with lower-grade gliomas based on LASSO-Cox regression: a population-based cohort …

X Niu, T Chang, Y Zhang, Y Liu, Y Yang… - Frontiers in …, 2024 - frontiersin.org
Background This study aimed to identify prognostic factors for survival and develop a
prognostic nomogram to predict the survival probability of elderly patients with lower-grade …

Treatment Strategies for Glioblastoma in the Elderly: What Should We Focus on Compared to Younger Patients

HH Gull, AC Von Riegen, GT Beckmann, P Ketelauri… - Cancers, 2024 - mdpi.com
Simple Summary Although the incidence of glioblastoma (GB) in people over 65 years is
more than twice as high as in younger people, no standard of care for the treatment of the …