The pharmacological properties of the novel antipsychotic drugs (APDs) risperidone,
sertindole, olanzapine, quetiapine, ziprasidone, remoxipride, and amperozide are reviewed …

Rationale Latent inhibition (LI), namely, poorer performance on a learning task involving a
previously pre-exposed non-reinforced stimulus, is disrupted in the rat by the dopamine (DA) …

An endophenotype is a heritable trait that is generally considered to be more highly,
associated with a gene-based neurological deficit than a disease phenotype itself. Such …

Latent Inhibition (LI) is an attentional phenomenon in which repeated pre-exposure to a
stimulus that is not reinforced retards future associability to that stimulus. LI adaptively allows …

The nature of the primary symptoms of schizophrenia and our lack of knowledge of its
underlying cause both contribute to the difficulty of generating convincing animal models of …

Latent inhibition (LI) is demonstrated when a previously unattended/inconsequential
stimulus is less effective in a new learning situation than a novel stimulus. In rats and …

Organisms exposed to a stimulus which has no significant consequences, show
subsequently latent inhibition (LI), namely, retarded conditioning to this stimulus. LI is …

Latent inhibition (LI) is a cross species selective attention phenomenon reflecting a
modulating effect of past experience with inconsequential stimuli on current task …

Background: Prepulse inhibition and latent inhibition are the two animal paradigms currently
dominating neuropharmacological research on attentional deficits in schizophrenia. Both …

S 16924 antagonized locomotion provoked by dizocilpine and cocaine, reduced conditioned
avoidance responses and blocked climbing elicited by apomorphine, models predictive of …