Stress and fear extinction

S Maren, A Holmes - Neuropsychopharmacology, 2016 - nature.com
Stress has a critical role in the development and expression of many psychiatric disorders,
and is a defining feature of posttraumatic stress disorder (PTSD). Stress also limits the …

Human memory reconsolidation: A guiding framework and critical review of the evidence.

JWB Elsey, VA Van Ast, M Kindt - Psychological bulletin, 2018 - psycnet.apa.org
Research in nonhuman animals suggests that reactivation can induce a transient, unstable
state in a previously consolidated memory, during which the memory can be disrupted or …

Memory reconsolidation interference as an emerging treatment for emotional disorders: strengths, limitations, challenges, and opportunities

T Beckers, M Kindt - Annual review of clinical psychology, 2017 - annualreviews.org
Experimental research on emotional memory reconsolidation interference, or the induction
of amnesia for previously established emotional memory, has a long tradition, but the …

Neurobiology of comorbid post‐traumatic stress disorder and alcohol‐use disorder

NW Gilpin, JL Weiner - Genes, Brain and Behavior, 2017 - Wiley Online Library
Post‐traumatic stress disorder (PTSD) and alcohol‐use disorder (AUD) are highly comorbid
in humans. Although we have some understanding of the structural and functional brain …

A locus coeruleus to dentate gyrus noradrenergic circuit modulates aversive contextual processing

D Seo, ET Zhang, SC Piantadosi, DJ Marcus… - Neuron, 2021 - cell.com
Dysregulation in contextual processing is believed to affect several forms of
psychopathology, such as post-traumatic stress disorder (PTSD). The dentate gyrus (DG), a …

Propranolol versus other selected drugs in the treatment of various types of anxiety or stress, with particular reference to stage fright and post-traumatic stress disorder

Ł Szeleszczuk, D Frączkowski - International journal of molecular …, 2022 - mdpi.com
Propranolol, a non-cardioselective β1, 2 blocker, is most commonly recognised for its
application in the therapy of various cardiovascular conditions, such as hypertension …

Understanding the dynamic and destiny of memories

L de Oliveira Alvares, FH Do-Monte - Neuroscience & Biobehavioral …, 2021 - Elsevier
Memory formation enables the retention of life experiences overtime. Based on previously
acquired information, organisms can anticipate future events and adjust their behaviors to …

Drug memory reconsolidation: from molecular mechanisms to the clinical context

AL Milton - Translational Psychiatry, 2023 - nature.com
Since its rediscovery at the beginning of the 21st Century, memory reconsolidation has been
proposed to be a therapeutic target for reducing the impact of emotional memories that can …

A novel approach to PTSD modeling in rats reveals alternating patterns of limbic activity in different types of stress reaction

G Ritov, B Boltyansky, G Richter-Levin - Molecular psychiatry, 2016 - nature.com
Human reactions to trauma exposure are extremely diverse, with some individuals exhibiting
only time-limited distress and others qualifying for posttraumatic stress disorder diagnosis …

Modulation of fear extinction by stress, stress hormones and estradiol: a review

U Stockhorst, MI Antov - Frontiers in behavioral neuroscience, 2016 - frontiersin.org
Fear acquisition and extinction are valid models for the etiology and treatment of anxiety,
trauma-and stressor-related disorders. These disorders are assumed to involve aversive …