Necroptosis is a form of regulated cell death, which is induced by ligand binding to TNF
family death domain receptors, pattern recognizing receptors and virus sensors. The …

Ca2+ plays a crucial role in connecting membrane excitability with contraction in
myocardium. The hallmark features of heart failure are mechanical dysfunction and …

Many signals have risen and fallen in the tide of investigation into mechanisms of
myocardial hypertrophy and heart failure (HF). In our opinion, the multifunctional Ca and …

Understanding relationships between heart failure and arrhythmias, important causes of
suffering and sudden death, remains an unmet goal for biomedical researchers and …

About 10 distinct potassium channels in the heart are involved in shaping the action
potential. Some of the K+ channels are primarily responsible for early repolarization …

Abstract Calcium (Ca2+) is the central second messenger in the translation of electrical
signals into mechanical activity of the heart. This highly coordinated process, termed …

Calcium/calmodulin-dependent protein kinase II (CaMKII) is upregulated in diabetes and
significantly contributes to cardiac remodeling with increased risk of cardiac arrhythmias …

Cardiac repolarization abnormalities can be caused by a wide range of cardiac and non‐
cardiac compounds and may lead to the development of life‐threatening Torsades de …

Chronic hyperglycemia and diabetes lead to impaired cardiac repolarization, K+ channel
remodeling and increased arrhythmia risk. However, the exact signaling mechanism by …

Rapidly activating and inactivating cardiac transient outward K+ currents, Ito, are expressed
in most mammalian cardiomyocytes, and contribute importantly to the early phase of action …