Recent developments of stereoselective biocatalytic and chemocatalytic methods are
discussed. The review provides a guide to the use of biocatalytic methods in the area of …

Transition metal catalysis is a powerful means of effecting organic reactions, but it has some
inherent drawbacks, such as the cost of the catalyst and the toxicity of the metals …

The ongoing trends to process improvements, cost reductions and increasing quality, safety,
health and environment requirements of industrial chemical transformations have …

Carbon–carbon bond formation is the key reaction for organic synthesis to construct the
carbon framework of organic molecules. The review gives a selection of biocatalytic C–C …

Many successful stories in enzyme engineering are based on the creation of randomized
diversity in large mutant libraries, containing millions to billions of enzyme variants. Methods …

Enzymes, at the turn of the 21st century, are gaining a momentum. Especially in the field of
synthetic organic chemistry, a broad variety of biocatalysts are being applied in an …

Comprehensive Summary NiH‐catalyzed multicomponent reductive hydrofunctionalization
of alkenes is an attractive but poorly explored approach to rapidly increasing molecular …

Carbon‐carbon bond formation is among the most challenging transformations in the
organic synthetic chemistry. Enzymes capable to perform this reaction are of great interest …

Reduction, please! The title reaction affords α-hydroxyketones, a common structural motif in
biologically active natural products, in good yields and high enantioselectivities at room …

We describe an efficient continuous flow synthesis of ketones from CO2 and organolithium
or Grignard reagents that exhibits significant advantages over conventional batch conditions …