The cornea serves as a vital protective barrier for the eye; however, it is prone to injury and
damage that can disrupt corneal epithelium and nerves, triggering inflammation. Therefore …

Blood-derived preparations, including autologous or allogenic serum, umbilical cord
serum/plasma, and platelet-rich plasma eye drops, contain various growth factors, cytokines …

The disappearance of the protective barrier after skin injury leads to the overproduction of
reactive oxygen species (ROS) in response to various stimuli. Oxidative stress is one of the …

This chapter reviews relevant characteristics of selective nonpeptide NK-1R antagonists,
with potential therapeutical application in several human pathologies besides actual use to …

Neuropathic pain, one of the most refractory pain diseases, remains a formidable medical
challenge. There is still an unmet demand for effective and safe therapies to address this …

Substance P (SP) expressed by corneal nerves, is an 11-amino acid long neuropeptide from
the tachykinin family, encoded by the Tac1 gene, and binds to neurokinin receptors. SP …

Purpose: This study aims to assess the efficacy of two aprepitant formulations (X1 and X2),
in a preclinical model of dry eye disease (DED) induced by benzalkonium chloride (BAK) …

The tachykinin substance P is a vasoactive neuropeptide with a recognized role in
nociception, but it is increasingly appreciated to play a role in the initiation and progression …

This study demonstrates the potential of using orally disintegrating tablets (ODTs) as a
delivery vehicle for Aprepitant to manage chemotherapy-induced vomiting effectively …