The human innate and adaptive immune systems consist of effector cells producing
cytokines (interleukins, interferons, chemokines, and numerous other mediators). Usually, a …

The complement system was discovered at the end of the 19th century as a heat-labile
plasma component that “complemented” the antibodies in killing microbes, hence the name …

This report compiles and summarizes all recommendations from CDC's Advisory Committee
on Immunization Practices (ACIP) for use of meningococcal vaccines in the United States …

The past 2 decades have seen a revolution in our approach to therapeutic
immunosuppression. We have moved from relying on broadly active traditional medications …

Sepsis, a life threating syndrome characterized by organ failure after infection, is the most
common cause of death in hospitalized patients. The treatment of sepsis is generally …

Our understanding and management of atypical hemolytic uremic syndrome (aHUS) have
dramatically improved in the last decade. aHUS has been established as a prototypic …

Complement defects are associated with an enhanced risk of a broad spectrum of infectious
as well as systemic or local inflammatory and thrombotic disorders. Inherited complement …

This article presents the results of group discussion among an ad hoc constituted panel of
experts aimed at identifying and addressing unmet clinical needs (UCNs) in the …

Paroxysmal nocturnal haemoglobinuria (PNH) is a rare acquired haematopoietic stem cell
disease characterized by complement-mediated intravascular hemolysis, thrombosis, and …

Introduction Eculizumab is a licensed treatment for several rare, complement-mediated
diseases. Eculizumab use is associated with an approximately 2,000-fold increased …