Proprotein convertase subtilisin/kexin type 9 (PCSK9), mainly synthetized and released by
the liver, represents one of the key regulators of low-density lipoprotein cholesterol …

Primary and secondary prevention protocols aim at reducing the plasma levels of lipids-with
particular reference to low-density lipoprotein cholesterol (LDL-C) plasma concentrations–in …

Diabetes is associated with an increased risk of heart failure (HF). This is commonly termed
diabetic cardiomyopathy and is often characterised by increased cardiac fibrosis …

Many human diseases may benefit from adiponectin replacement therapy, but due to
pharmacological disadvantages of the intact protein, druggable options focus on peptidic …

Adiponectin replacement therapy holds the potential to benefit numerous human diseases,
and ongoing research applies particular interest in how adiponectin acts against Metabolic …

In a condition of dysfunctional visceral fat depots, as in the case of obesity, alterations in
adipokine levels may be detrimental for the cardiovascular system. The proinflammatory …

e138 Arterioscler Thromb Vasc Biol August 2018 major difference between these 2 studies
is Gao et al's10 focus on long-term effects of variances in normal levels of sodium levels …

Duchenne muscular dystrophy (DMD) is one of the most devastating myopathies, where
severe inflammation exacerbates disease progression. Previously, we demonstrated that …

Doxorubicin (DOX) is an anthracycline derivative and widely used as an anticancer drug.
However, the severe cardiotoxicity of DOX limits its application. ADP355 is an adiponectin …

The formation of a thrombus is closely related to oxidative stress and inflammation.
Colchicine is one of the most commonly prescribed medication for gout treatment, with anti …