Formation, physiology, ecology, evolution and clinical importance of bacterial persisters

B Van den Bergh, M Fauvart… - FEMS microbiology …, 2017 - academic.oup.com
Persisters are transiently tolerant variants that allow populations to avoid eradication by
antibiotic treatment. Their antibiotic tolerance is non-genetic, not inheritable and results from …

Horizontal gene transfer in the human gastrointestinal tract: potential spread of antibiotic resistance genes

JR Huddleston - Infection and drug resistance, 2014 - Taylor & Francis
Bacterial infections are becoming increasingly difficult to treat due to widespread antibiotic
resistance among pathogens. This review aims to give an overview of the major horizontal …

Experimental design, population dynamics, and diversity in microbial experimental evolution

B Van den Bergh, T Swings, M Fauvart… - … and Molecular Biology …, 2018 - Am Soc Microbiol
In experimental evolution, laboratory-controlled conditions select for the adaptation of
species, which can be monitored in real time. Despite the current popularity of such …

Mechanisms of DNA uptake by naturally competent bacteria

D Dubnau, M Blokesch - Annual review of genetics, 2019 - annualreviews.org
Transformation is a widespread mechanism of horizontal gene transfer in bacteria. DNA
uptake to the periplasmic compartment requires a DNA-uptake pilus and the DNA-binding …

Natural competence and the evolution of DNA uptake specificity

JC Mell, RJ Redfield - Journal of bacteriology, 2014 - Am Soc Microbiol
Many bacteria are naturally competent, able to actively transport environmental DNA
fragments across their cell envelope and into their cytoplasm. Because incoming DNA …

Cues and regulatory pathways involved in natural competence and transformation in pathogenic and environmental Gram-negative bacteria

P Seitz, M Blokesch - FEMS microbiology reviews, 2013 - academic.oup.com
Bacterial genomics is flourishing, as whole-genome sequencing has become affordable,
readily available and rapid. As a result, it has become clear how frequently horizontal gene …

Pharmacodynamics, Population Dynamics, and the Evolution of Persistence in Staphylococcus aureus

PJT Johnson, BR Levin - PLoS genetics, 2013 - journals.plos.org
When growing populations of bacteria are confronted with bactericidal antibiotics, the vast
majority of cells are killed, but subpopulations of genetically susceptible but phenotypically …

Horizontal DNA transfer mechanisms of bacteria as weapons of intragenomic conflict

NJ Croucher, R Mostowy, C Wymant, P Turner… - PLoS …, 2016 - journals.plos.org
Horizontal DNA transfer (HDT) is a pervasive mechanism of diversification in many microbial
species, but its primary evolutionary role remains controversial. Much recent research has …

Long-term industrial metal contamination unexpectedly shaped diversity and activity response of sediment microbiome

S Jacquiod, V Cyriaque, L Riber, WA Al-Soud… - Journal of hazardous …, 2018 - Elsevier
Metal contamination poses serious biotoxicity and bioaccumulation issues, affecting both
abiotic conditions and biological activity in ecosystem trophic levels, especially sediments …

Self-sensing in Bacillus subtilis quorum-sensing systems

T Bareia, S Pollak, A Eldar - Nature Microbiology, 2018 - nature.com
Bacterial cell–cell signalling, or quorum sensing, is characterized by the secretion and
groupwide detection of small diffusible signal molecules called autoinducers. This …