Metastasis accounts for 90% of breast cancer mortality. Despite the significant progress
made over the past decade in cancer medicine our understanding of metastasis remains …

The skeleton is one of the most common sites for metastatic cancer, and tumors arising from
the breast or prostate possess an increased propensity to spread to this site. The growth of …

The bone matrix is constantly remodeled by bone-resorbing osteoclasts and bone-forming
osteoblasts. These two cell types are fundamentally different in terms of progenitor cells …

Chemokines play a paramount role in the tumor progression. Chronic inflammation
promotes tumor formation. Both tumor cells and stromal cells elaborate chemokines and …

The most common skeletal complication of breast cancer is osteolytic bone metastasis. Bone
metastases are present in 80% of patients with advanced disease and cause significant …

The skeleton is a common destination for many cancer metastases including breast and
prostate cancer. There are many characteristics of bone that make it an ideal environment …

The spine is a frequent location for metastatic disease. As local control of primary tumor
pathology continues to improve, survival rates improve and, by extension, the opportunity for …

Background Breast cancer is a notable cause of cancer-related death in women worldwide.
Metastasis to distant organs is responsible for~ 90% of this death. Breast cells convert to …

Bone is a common site of cancer metastasis. Breast, prostate, and lung cancers show a
predilection to metastasize to bone. Recently, we reported that the chemokine interleukin 8 …

Earlier studies reported allelic deletion of the essential autophagy regulator BECN1 in
breast cancers implicating BECN1 loss, and likely defective autophagy, in tumorigenesis …