Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …

DNA single-strand breaks (SSBs) are among the most common lesions arising in human
cells, with tens to hundreds of thousands arising in each cell, each day. Cells have efficient …

Abstract Analysis of mutational signatures can reveal underlying molecular mechanisms of
the processes that have imprinted the somatic mutations found in cancer genomes. Here, we …

Genome damage and transcription are intimately linked. Tens to hundreds of thousands of
DNA lesions arise in each cell each day, many of which can directly or indirectly impede …

Translesion DNA synthesis (TLS) facilitates replication over damaged or difficult-to-replicate
templates by employing specialized DNA polymerases. We investigate the effect on …

Abstract Formamidopyrimidine (Fapy• dG) is a major lesion arising from oxidation of dG that
is produced from a common chemical precursor of 8-oxo-7, 8-dihydro-2′-deoxyguanosine …

The genome of each cell in the human body is constantly under assault from a plethora of
exogenous and endogenous processes that can damage DNA. If not successfully repaired …

Pesticides are significant environmental pollutants, and many of them possess mutagenic
potential, which is closely linked to carcinogenesis. Here we tested the mutagenicity of all six …

DNA methylation is important for establishing and maintaining cell identity and for genomic
stability. This is achieved by regulating the accessibility of regulatory and transcriptional …

Schizosaccharomyces pombe is an ascomycete fungus that divides by medial fission; it is
thus commonly referred to as fission yeast, as opposed to the distantly related budding yeast …