Bacteria have evolved many different signal transduction systems that sense signals and
generate a variety of responses. Generally, most abundant are transcriptional regulators …

The mycobacterial repressor, DarR, a TetR family regulator (TFR), was the first transcription
regulator shown to bind c-di-AMP. However, the molecular basis for this interaction and the …

TetR family regulators (TFRs) represent a large group of one-component bacterial signal
transduction systems which recognize environmental signals, like the presence of antibiotics …

Transcriptional regulation is a critical adaptive mechanism that allows bacteria to respond to
changing environments, yet the concept of transcriptional plasticity (TP)–the variability of …

Host-derived fatty acids are an important carbon source for pathogenic mycobacteria during
infection. How mycobacterial cells regulate the catabolism of fatty acids to serve the …

Tetracycline repressor (TetR) family regulators (TFRs) are the largest group of DNA-binding
transcription factors and are widely distributed in bacteria and archaea. TFRs play vital roles …

Bacteria constantly monitor their environment to adapt their inner makeup. Beyond providing
chemical sustenance, metabolism provides most of the feedback on the cellular environment …

One of the tenets of molecular biology is that dynamic transitions between three-dimensional
structures determine the function of proteins. Therefore, it seems only natural that …

Crystallography at low resolution must determine the atomic model from less experimental
observations, which is challenging in the absence of a model. In addition, model bias is …

The production of secondary metabolites is a major mechanism used by beneficial
rhizobacteria to antagonize plant pathogens. These bacteria have evolved to coordinate the …