Many fundamental processes in cell biology are regulated by Rho GTPases, including cell
adhesion, migration and differentiation. While regulating cellular functions, members of the …

The Rho subfamily members of Rho GTPases, RhoA, RhoB, and RhoC, are key regulators
of signal transduction in a variety of cellular processes, including regulation of actomyosin …

Several studies suggest that RhoA and RhoC, despite their sequence similarity, have
different roles in cell migration and invasion, but the molecular basis for this is not known …

Background MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs
that regulate gene expression at post-transcriptional level. The recent discovery of the …

The cyclical protrusion and retraction of the leading edge is a hallmark of many migrating
cells involved in processes such as development, inflammation and tumorigenesis. The …

RhoB is a Rho family GTPase that is highly similar to RhoA and RhoC, yet has distinct
functions in cells. Its unique C-terminal region is subject to specific post-translational …

Rho GTPases are a class of evolutionarily conserved proteins comprising 20 members,
which are predominantly known for their role in regulating the actin cytoskeleton. They are …

Despite decades of study, elucidation of the underlying etiology of complex developmental
disorders such as autism spectrum disorder (ASD), schizophrenia (SCZ), intellectual …

Abstract RNA G-quadruplexes (G4s) are secondary structures proposed to function as
regulators of post-transcriptional mRNA localisation and translation. G4s within some …

ATP, released at the leading edge of migrating neutrophils, amplifies chemotactic signals.
The aim of our study was to investigate whether neutrophils express ATP-gated P2X 1 ion …