Complex physiological processes control whether stem cells self-renew, differentiate or
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …

Hippo pathway components are structurally and functionally conserved and are notable for
their role in controlling organ size. More diverse functions of the Hippo pathway have been …

YAP (yes-associated protein) is a transcriptional factor that is negatively regulated by Hippo
pathway, a conserved pathway for the development and size control of multiple organs. The …

Transforming growth factor-β (TGF-β) family members, which include TGF-βs, activins and
bone morphogenetic proteins, are pleiotropic cytokines that elicit cell type-specific effects in …

The Hippo signaling pathway is a central growth control mechanism in multicellular
organisms. By integrating diverse mechanical, biochemical, and stress cues, the Hippo …

Netrin-1 was the first axon guidance molecule to be discovered in vertebrates and has a
strong chemotropic function for axonal guidance, cell migration, morphogenesis and …

Rationale: Optic neuritis is one of main symptoms in multiple sclerosis (MS) that causes
visual disability. Astrocytes are pivotal regulators of neuroinflammation in MS, and astrocytic …

The most frequent reason of morbidity and mortality in the world, cerebral ischemia sets off a
chain of molecular and cellular pathologies that associated with some central nervous …

Yes-associated protein (YAP) transcriptional coactivator is negatively regulated by the Hippo
pathway and functions in controlling the size of multiple organs, such as liver during …

Exposure to a growth factor abundant milieu has remarkable regenerative and rejuvenating
effects on organ diseases, tissue damage, and regeneration, including skeletal system …